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6-Carboxyfluorescein N-succinimidyl ester | 92557-81-8
| Catelog Number | R01-0025 |
| Category | Fluorescein FAM |
| Molecular Formula | C25H15NO9 |
| Molecular Weight | 473.393 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0025 | 500 mg | $299 |
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Product Introduction
6-Carboxyfluorescein N-succinimidyl ester is the amine-reactive succinimidyl ester carboxyfluorescein that is used in the labeling of nucleotides and nucleic acids.
Chemical Information |
|
|---|---|
| Synonyms | FAM NHS ester, 6-isomer;OSu-FAM; 6-FAM, SE; 6-FAM SE; 6-Carboxyfluorescein-NHS; 6-Carboxyfluorescein N-hydroxysuccinimide ester; (2,5-dioxopyrrolidin-1-yl) 3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate |
| Purity | NMR 1H, HPLC-MS (95%) |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)C2=CC3=C(C=C2)C(=O)OC34C5=C(C=C(C=C5)O)OC6=C4C=CC(=C6)O |
| InChI | InChI=1S/C25H15NO9/c27-13-2-5-16-19(10-13)33-20-11-14(28)3-6-17(20)25(16)18-9-12(1-4-15(18)24(32)34-25)23(31)35-26-21(29)7-8-22(26)30/h1-6,9-11,27-28H,7-8H2 |
| InChI Key | VDABVNMGKGUPEY-UHFFFAOYSA-N |
| Solubility | good in DMF, DMSO |
| Appearance | yellow crystalline solid |
Product Specification |
|
|---|---|
| ε, L⋅mol-1⋅cm-1 | 75000 |
| Fluorescence Quantum Yield | 0.9 |
| Excitation | 494 |
| Emission | 520 |
| Storage | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
Computed Properties | |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 3 |
| Exact Mass | 473.07468106 g/mol |
| Monoisotopic Mass | 473.07468106 g/mol |
| Topological Polar Surface Area | 140Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 894 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 9285 | 1976-09-01 | Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo | European journal of biochemistry |
| 9285 | 1976-09-01 | Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo | European journal of biochemistry |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114533875-A | Application of 2-cyanophenacene compounds in the preparation of drugs for the treatment of drug-resistant tumors | 2022-01-27 |
| CN-114099682-A | Use of PI3Kγ inhibitors in the treatment of residual tumors by radiofrequency ablation | 2021-12-07 |
| US-11359012-B1 | Specific chimeric antigen receptor cells targeting human CLDN18A2, preparation method and application thereof | 2021-08-27 |
| EP-4112640-A1 | Novel single domain antigen binding molecules and their uses | 2021-06-29 |
| WO-2023275075-A1 | Novel single domain antigen binding molecules and their uses | 2021-06-29 |
Applications of Fluorescent Probes & Dyes
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