Ac-WLA-AMC | 1104011-59-7

Catalog Number	A18-0050
Category	Fluorescent Enzyme Substrates
Molecular Formula	C32H37N5O6
Molecular Weight	587.7

Catalog Number	Size	Price	Quantity
A18-0050	--	$--

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Product Introduction

Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.

Chemical Information
Synonyms	Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin; N-acetyl-L-tryptophyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alaninamide
Purity	≥95%
IUPAC Name	(2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]pentanamide
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C
InChI	InChI=1S/C32H37N5O6/c1-17(2)12-26(37-32(42)27(35-20(5)38)14-21-16-33-25-9-7-6-8-24(21)25)31(41)34-19(4)30(40)36-22-10-11-23-18(3)13-29(39)43-28(23)15-22/h6-11,13,15-17,19,26-27,33H,12,14H2,1-5H3,(H,34,41)(H,35,38)(H,36,40)(H,37,42)/t19-,26-,27-/m0/s1
InChI Key	PIJMRHCPKXLMIS-DOYMOWJKSA-N
Appearance	Solid Powder

Product Specification

Excitation	351 nm
Emission	430 nm
Storage	Store at -20°C

Computed Properties
XLogP3	3.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	11
Exact Mass	587.27438392 g/mol
Monoisotopic Mass	587.27438392 g/mol
Topological Polar Surface Area	159Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1090
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Applications of Fluorescent Probes & Dyes

Laser Dye

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Ac-WLA-AMC | 1104011-59-7

Product Introduction

Chemical Information

Computed Properties