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Ac-PAL-AMC | 1431362-79-6
| Catelog Number | A18-0053 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C26H34N4O6 |
| Molecular Weight | 498.6 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0053 | -- | $-- |
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Product Introduction
Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. It can be cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome.
Chemical Information |
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|---|---|
| Synonyms | Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin; 1-acetyl-L-prolyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-leucinamide |
| Purity | ≥95% |
| IUPAC Name | (2S)-1-acetyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C3CCCN3C(=O)C |
| InChI | InChI=1S/C26H34N4O6/c1-14(2)11-20(25(34)28-18-8-9-19-15(3)12-23(32)36-22(19)13-18)29-24(33)16(4)27-26(35)21-7-6-10-30(21)17(5)31/h8-9,12-14,16,20-21H,6-7,10-11H2,1-5H3,(H,27,35)(H,28,34)(H,29,33)/t16-,20-,21-/m0/s1 |
| InChI Key | BWJPVHDZSJFFDM-NDXORKPFSA-N |
| Appearance | Solid Powder |
Product Specification |
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|---|---|
| Excitation | 351 nm |
| Emission | 430 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 8 |
| Exact Mass | 498.24783482 g/mol |
| Monoisotopic Mass | 498.24783482 g/mol |
| Topological Polar Surface Area | 134Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 916 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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