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Fluorescein-DBCO | CAS 2054339-00-1
| Catalog Number | F04-0008 |
| Category | Fluorescein FAM |
| Molecular Formula | C39H27N3O6S |
| Molecular Weight | 665.71 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | DBCO-FITC(5-isomer) |
| Purity | >98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | |
| Canonical SMILES | C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O |
| InChI | InChI=1S/C39H27N3O6S/c43-27-12-15-31-34(20-27)47-35-21-28(44)13-16-32(35)39(31)30-14-11-26(19-29(30)37(46)48-39)41-38(49)40-18-17-36(45)42-22-25-7-2-1-5-23(25)9-10-24-6-3-4-8-33(24)42/h1-8,11-16,19-21,43-44H,17-18,22H2,(H2,40,41,49) |
| InChIKey | FGEDVMJBPDYXLU-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Appearance | Solid |
| Excitation | 494 |
| Emission | 517 |
| Storage | Store at -5°C,keep in dry and avoid sunlight. |
Fluorescein-DBCO, a compound with fluorescent labeling, plays a pivotal role in various biochemical applications. Explore four key applications of Fluorescein-DBCO with enhanced perplexity and burstiness:
Bioorthogonal Chemistry: Leveraging Fluorescein-DBCO in bioorthogonal chemistry allows for the precise labeling of biomolecules without interference. When coupled with azide-containing molecules, it facilitates the visualization and tracking of these biomolecules within living cells. This application is indispensable for real-time examination of cellular processes, shedding light on intricate biological interactions.
Protein Labeling: By enabling the fluorescent labeling of proteins, Fluorescein-DBCO simplifies the detection and analysis of protein interactions and functions. This capability proves particularly beneficial in fluorescence microscopy and flow cytometry, where labeled proteins can be monitored within cells or scrutinized for binding events and functional assessments. Researchers can delve deeply into protein dynamics and cellular localization, unraveling the complexities of cellular behavior.
DNA and RNA Labeling: Fluorescein-DBCO serves as a valuable tool for labeling nucleic acids, aiding in the investigation of gene expression and nucleic acid-protein interactions. This application allows for the visualization of DNA and RNA within cells, contributing to the understanding of transcription, replication, and translation mechanisms. The fluorescently labeled nucleic acids offer critical insights into genome organization and regulation, enhancing our understanding of genetic processes.
Drug Delivery Research: In the realm of drug delivery studies, Fluorescein-DBCO can be conjugated to therapeutic molecules, enabling the monitoring of their distribution and localization within biological systems. This capability empowers researchers to track the delivery and release of drugs at the cellular level, ensuring targeted delivery to intended sites. Such applications are essential for optimizing drug delivery systems and enhancing therapeutic efficacy, advancing the landscape of drug development and administration.
| XLogP3 | 5.6 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 4 |
| Exact Mass | 665.16205676 g/mol |
| Monoisotopic Mass | 665.16205676 g/mol |
| Topological Polar Surface Area | 152Ų |
| Heavy Atom Count | 49 |
| Formal Charge | 0 |
| Complexity | 1320 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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