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Fluo-3 | 123632-39-3
| Catelog Number | A21-0015 |
| Category | Calcium, Chloride Indictors and Other indicators |
| Molecular Formula | C36H30Cl2N2O13 |
| Molecular Weight | 769.54 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A21-0015 | -- | $-- |
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Product Introduction
Fluo-3 is a fluorescent indicator for calcium that is commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels.
Chemical Information |
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|---|---|
| Related CAS | 121714-13-4 (Deleted CAS) 122295-33-4 (Deleted CAS) 129038-44-4 (Deleted CAS) 339221-91-9 (pentaammonium salt) 853400-67-6 (pentapotassium salt) |
| Synonyms | Glycine, N-[2-[2-[2-[bis(carboxymethyl)amino]-5-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy]ethoxy]-4-methylphenyl]-N-(carboxymethyl)-; N-[2-[2-[2-[Bis(carboxymethyl)amino]-5-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy]ethoxy]-4-methylphenyl]-N-(carboxymethyl)glycine; Fluo 3; Fluo3; 4-(2,7-Dichloro-6-hydroxy-3-oxo-9-xanthenyl)-4-methyl-2,2-(ethylenedioxy)dianiline-N,N,N,N-tetraacetic acid; FLUO 3 |
| Purity | 95% |
| IUPAC Name | 2-[2-[2-[2-[bis(carboxymethyl)amino]-5-(2,7-dichloro-3-hydroxy-6-oxoxanthen-9-yl)phenoxy]ethoxy]-N-(carboxymethyl)-4-methylanilino]acetic acid |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)O)CC(=O)O)OCCOC2=C(C=CC(=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)Cl)O)Cl)N(CC(=O)O)CC(=O)O |
| InChI | InChI=1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50) |
| InChI Key | OZLGRUXZXMRXGP-UHFFFAOYSA-N |
| Solubility | Soluble in Water |
| Density | 1.66±0.1 g/cm3 |
| Boiling Point | 1056.0±65.0°C at 760 Torr |
| MDL Number | MFCD00083337 |
| NACRES | NA.32 |
Product Specification |
|
|---|---|
| Excitation | 506 |
| Emission | 526 |
| Properties Quality Level | 100 |
| Storage | Store at -20°C |
| Application | Fluo-3 and related molecule Fluo3/AM are used as a fluorescence indicator of intracellular calcium (Ca2+). Fluo-3 may be use for flow cytometry and confocal laser scanning microscopy using visible light excitation (compatible with argon laser sources operating at 488 nm). Fluorescence intensity increases about 40-fold after calcium binding. |
Computed Properties | |
|---|---|
| XLogP3 | 5 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 16 |
| Exact Mass | 768.1124944 g/mol |
| Monoisotopic Mass | 768.1124944 g/mol |
| Topological Polar Surface Area | 221Ų |
| Heavy Atom Count | 53 |
| Formal Charge | 0 |
| Complexity | 1490 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 30880218 | 2019-05-01 | Stimulation of eryptosis by broad-spectrum insect repellent N,N-Diethyl-3-methylbenzamide (DEET) | Toxicology and applied pharmacology |
| 23069259 | 2012-12-16 | Stimulation of suicidal death of erythrocytes by rifampicin | Toxicology |
| 22885103 | 2012-12-01 | Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes | Cellular signalling |
| 23022152 | 2012-12-01 | Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells: modulation by the polyphenols quercetin, resveratrol and rutin | Biochimica et biophysica acta |
| 22728055 | 2012-11-01 | Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Aster tataricus | International journal of biological macromolecules |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114875070-A | A kind of GLP-1R high expression vector and recombinant HEK293 cell based thereon and construction method and application | 2022-06-20 |
| CN-115165711-A | Preparation method of fluorescent coded magnetic beads based on liquid chip technology | 2022-04-20 |
| CN-114863996-A | A rapid method for assessing neurotoxicity of bisphenols | 2022-04-18 |
| WO-2022078524-A2 | Specific conjugation of an antibody | 2021-11-03 |
| WO-2022078524-A4 | Specific conjugation of an antibody | 2021-11-03 |
Applications of Fluorescent Probes & Dyes
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