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FAM Maleimide
| Catalog Number | F04-0048 |
| Category | Fluorescein FAM |
| Molecular Formula | C27H18N2O8 |
| Molecular Weight | 500.1 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
FAM Maleimide is a thiol reactive bright green dye used to generate a stable fluorescence signal in bioimaging. The maxima of Ex/Em values are at 494/520 nm, similar to that of Alexa 488 and Cy2. FAM might be excited using 488 nm laser line and displays good optical property. Maleimides selectively label thiols of cysteine residue via 1,4-addition pathway, without interacting with amines, to form thioether linkage. Maleimides apparently do not react with methionine, histidine or tyrosine, but they might react with primary amines under strong basic environment. We offer FAM maleimide for labeling of thiols on antibodies, peptides, proteins and nucleotide.
Chemical Information
Product Specification
Computed Properties
| Synonyms | 5-FAM Maleimide |
| IUPAC Name | N-[2-(2,5-dioxopyrrol-1-yl)ethyl]-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxamide |
| Canonical SMILES | C1=CC2=C(C=C1C(=O)NCCN3C(=O)C=CC3=O)C(=O)OC24C5=C(C=C(C=C5)O)OC6=C4C=CC(=C6)O |
| InChI | InChI=1S/C27H18N2O8/c30-15-2-5-19-21(12-15)36-22-13-16(31)3-6-20(22)27(19)18-4-1-14(11-17(18)26(35)37-27)25(34)28-9-10-29-23(32)7-8-24(29)33/h1-8,11-13,30-31H,9-10H2,(H,28,34) |
| InChIKey | INANBQGJVQTBLY-UHFFFAOYSA-N |
| Solubility | DMF, DMSO |
| Appearance | Yellow solid |
| CF280 | 0.3 |
| Excitation | 494 |
| Emission | 520 |
| Storage | -20 °C, protect from light |
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 4 |
| Exact Mass | 498.10631554 g/mol |
| Monoisotopic Mass | 498.10631554 g/mol |
| Topological Polar Surface Area | 143Ų |
| Heavy Atom Count | 37 |
| Formal Charge | 0 |
| Complexity | 968 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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