FAM hydrazide, 5-isomer

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FAM hydrazide, 5-isomer

FAM hydrazide, 5-isomer | 2183440-64-2

Catelog Number R05-0012
Category Fluorescein FAM
Molecular Formula C21H15N2ClO6
Molecular Weight 426.81
Catalog Number Size Price Quantity
R05-0012 -- $--

Product Introduction

Many natural and synthetic molecules contain aldehyde or ketone carbonyl groups. These carbonyls react with hydrazides with the formation of hydrazones. The reaction is spontaneous at pH values around neutral, and the resulting hydrazones are very stable.Compounds containing 1,2-diol function, like sugars, can be oxidized with sodium periodate with the formation of carbonyl compounds for the subsequent modification with hydrazides. This is an efficient method for the labeling of glycoproteins (like antibodies), and polysaccharides.

Chemical Information

Synonyms [(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]azanium
Purity NMR 1H, HPLC-MS (95%)
IUPAC Name [(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]azanium
Canonical SMILES C1=CC2=C(C=C1C(=O)N[NH3+])C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
InChI InChI=1S/C21H14N2O6/c22-23-19(26)10-1-4-14-13(7-10)20(27)29-21(14)15-5-2-11(24)8-17(15)28-18-9-12(25)3-6-16(18)21/h1-9,24-25H,22H2,(H,23,26)/p+1
InChI Key ZJLTXRWYPNRWBS-UHFFFAOYSA-O
Solubility good in ethanol, DMF, DMSO
Appearance yellow solid

Product Specification

ε, L⋅mol-1⋅cm-1 75000
Fluorescence Quantum Yield 0.9
Excitation 494
Emission 520
Storage 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Computed Properties

XLogP3 2
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 1
Exact Mass 391.09301120 g/mol
Monoisotopic Mass 391.09301120 g/mol
Topological Polar Surface Area 133Ų
Heavy Atom Count 29
Formal Charge 1
Complexity 660
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
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