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FAM amine, 6-isomer | 1313393-44-0
| Catelog Number | F04-0002 |
| Category | Fluorescein FAM |
| Molecular Formula | C27H27N2ClO6 |
| Molecular Weight | 510.97 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F04-0002 | -- | $-- |
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Product Introduction
FAM amine, 6-isomer is a remarkably versatile and indispensable fluorescent dye employed extensively in the biomedical industry, primarily serves the purpose of effectively and efficiently labeling nucleotides, proteins, and antibodies. Its vast range of applications spans cutting-edge techniques like fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) – essential tools pivotal to the comprehensive study of gene expression and protein localization.
Chemical Information |
|
|---|---|
| Related CAS | 2183440-42-6 (hydrochloride) |
| Synonyms | N-(6-Aminohexyl)-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxamide |
| Purity | NMR 1H, HPLC-MS (95%) |
| IUPAC Name | N-(6-aminohexyl)-3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxamide |
| Canonical SMILES | C1=CC2=C(C=C1C(=O)NCCCCCCN)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O |
| InChI | InChI=1S/C27H26N2O6/c28-11-3-1-2-4-12-29-25(32)16-5-8-19-22(13-16)27(35-26(19)33)20-9-6-17(30)14-23(20)34-24-15-18(31)7-10-21(24)27/h5-10,13-15,30-31H,1-4,11-12,28H2,(H,29,32) |
| InChI Key | YEKKULZAUQTCSI-UHFFFAOYSA-N |
| Solubility | good in methanol, DMSO, DMF |
| Appearance | yellow solid |
Product Specification |
|
|---|---|
| ε, L⋅mol-1⋅cm-1 | 80000 |
| Fluorescence Quantum Yield | 0.93 |
| Excitation | 490 |
| Emission | 513 |
| Storage | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
Computed Properties | |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 7 |
| Exact Mass | 474.17908655 g/mol |
| Monoisotopic Mass | 474.17908655 g/mol |
| Topological Polar Surface Area | 131Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 751 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2019331688-A1 | Screening methods for parp modulators | 2018-04-30 |
| WO-2019212946-A1 | Screening methods for parp modulators | 2018-04-30 |
| US-11293927-B2 | Screening methods for PARP modulators | 2018-04-30 |
| US-2022206008-A1 | Screening methods for parp modulators | 2018-04-30 |
| US-6320041-B1 | Pre-activated carbonyl linkers for the modification of oligonucleotides | 2001-04-13 |
Applications of Fluorescent Probes & Dyes
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