TCO TEG NHS carbonate

Name: TCO TEG NHS carbonate
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R15-0060
Category	Trans Cyclooctene (TCO)
Molecular Formula	C22H34N2O10
Molecular Weight	486.52

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Product Introduction

TCO TEG NHS carbonate is a bioorthogonal click chemistry reagent containing a trans-cyclooctene (TCO) group, a triethylene glycol (TEG) linker, and an N-hydroxysuccinimide (NHS) carbonate activated ester. The TCO group enables rapid inverse electron demand Diels-Alder (IEDDA) reactions with tetrazine-functionalized molecules, while the NHS carbonate reacts with primary amines to form stable carbamate bonds. It is used for efficient bioconjugation of proteins, peptides, and amino-modified oligonucleotides under mild, copper-free conditions.

Chemical Information

Chemical Information

Synonyms	(R,E)-Cyclooct-4-en-1-yl (1-((2,5-dioxopyrrolidin-1-yl)oxy)-1-oxo-2,5,8,11-tetraoxatridecan-13-yl)carbamate
SMILES	O=C1CCC(N1OC(OCCOCCOCCOCCNC(O[C@H]2CC/C=C/CCC2)=O)=O)=O
InChI	InChI=1S/C22H34N2O10/c25-19-8-9-20(26)24(19)34-22(28)32-17-16-31-15-14-30-13-12-29-11-10-23-21(27)33-18-6-4-2-1-3-5-7-18/h1-2,18H,3-17H2,(H,23,27)/b2-1+/t18-/m0/s1
InChIKey	SBJBHVVOXFBWNC-KROLTMCQSA-N