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TCO-PEG4-amine | CAS 2243569-24-4
| Catalog Number | R15-0024 |
| Category | Trans Cyclooctene (TCO) |
| Molecular Formula | C₁₉H₃₆N₂O₆ |
| Molecular Weight | 388.50 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TCO-PEG4-amine is a polyethylene glycol (PEG)-based PROTAC linker. TCO-PEG4-amine can be used in the synthesis of a series of PROTACs.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | (4E)-TCO-PEG4-amine |
| Purity | 95% |
| IUPAC Name | [(4Z)-cyclooct-4-en-1-yl] N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate |
| Canonical SMILES | C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCN |
| InChI | InChI=1S/C19H36N2O6/c20-8-10-23-12-14-25-16-17-26-15-13-24-11-9-21-19(22)27-18-6-4-2-1-3-5-7-18/h1-2,18H,3-17,20H2,(H,21,22)/b2-1- |
| InChIKey | RYDDYUPROQQUFL-UPHRSURJSA-N |
| Solubility | DMSO, DCM, DMF |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
TCO-PEG4-amine, a versatile chemical linker, finds diverse applications in bioconjugation and molecular labeling. Here are four key applications:
Biomedical Imaging: Utilizing TCO-PEG4-amine, researchers label biomolecules with imaging agents for real-time visualization of biological processes in living organisms. When coupled with fluorescent dyes or radioactive isotopes, it enables precise tracking of molecules within animal models.
Drug Delivery Systems: In the realm of advanced drug delivery systems, TCO-PEG4-amine plays a pivotal role. By attaching therapeutic agents to this innovative linker, researchers engineer targeted drug delivery mechanisms that enhance treatment efficacy and safety. This approach proves especially valuable in cancer therapy, where pinpoint targeting of tumor cells is paramount to successful outcomes.
Surface Coating: In the dynamic fields of nanotechnology and material sciences, TCO-PEG4-amine drives advancements in surface modification for nanoparticles and other materials. This modification optimizes biocompatibility and functional properties, expanding the use of materials in biomedical devices and implants. Moreover, it enhances stability and dispersity of nanoparticles in biological settings, fostering innovation in material design.
Proteomics: At the frontier of proteomics research, TCO-PEG4-amine emerges as a crucial reagent for unraveling the complexities of proteins and their interactions. By conjugating proteins with TCO-PEG4-amine, scientists can isolate, identify, and analyze protein complexes and their functions. This critical insight into disease pathways and potential drug targets propels the field forward, paving the way for transformative medical discoveries.
| XLogP3 | 0.7 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 16 |
| Exact Mass | 388.25733687 g/mol |
| Monoisotopic Mass | 388.25733687 g/mol |
| Topological Polar Surface Area | 101Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 381 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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