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TCO-PEG12-TFP ester | CAS 2353410-07-6
| Catalog Number | R15-0036 |
| Category | Trans Cyclooctene (TCO) |
| Molecular Formula | C42H67F4NO16 |
| Molecular Weight | 918.0 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TCO-PEG12-TFP ester is a click chemistry PEG PFP ester. The hydrophilic PEG12 spacer increases water-solubility and decreases steric hindrance during ligation. It can be used to label amine-containing antibodies, proteins or peptide molecules with TCO moiety. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters.
Chemical Information
Product Specification
Application
| Purity | 95% |
| Storage | -20 °C |
TCO-PEG12-TFP ester, a specialized reagent for bioconjugation and click chemistry, finds diverse applications in scientific research. Here are four key applications:
Protein Labeling: Widely utilized in biochemical and cell biology studies, TCO-PEG12-TFP ester enables site-specific labeling of proteins. By conjugating this reagent with target proteins, researchers can attach fluorescent markers or other probes, facilitating the monitoring of protein localization and interactions. This technique provides valuable insights into protein dynamics and function within live cells, shedding light on complex cellular processes.
Drug Delivery Research: In the realm of drug delivery systems, TCO-PEG12-TFP ester plays a crucial role in designing targeted delivery vehicles. By coupling this reagent with therapeutic molecules or drug carriers, precise delivery to specific cells or tissues is achieved. This targeted approach enhances drug efficacy while minimizing side effects, offering a tailored and efficient means of treating diseases with accuracy and precision.
Bioconjugation: Integral to bioconjugation protocols, TCO-PEG12-TFP ester serves as a key component for linking biomolecules such as peptides, antibodies, or nucleic acids. Its high specificity and efficiency facilitate the creation of complex bioconjugates essential for diagnostic, therapeutic, and research applications. This enhancement of biomolecular functionalization leads to improved stability and biological activity, advancing the utility of bioconjugates in various scientific endeavors.
Chemical Biology: A versatile tool in chemical biology research, TCO-PEG12-TFP ester enables the exploration of cellular processes through click chemistry techniques. By initiating bioorthogonal reactions that do not disrupt natural cellular functions, researchers can manipulate and visualize biomolecular interactions with precision. This approach allows for a detailed examination of complex biological environments, offering insights into intricate cellular mechanisms and interactions.
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