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TCO-PEG36-NHS ester
| Catalog Number | R15-0040 |
| Category | Trans Cyclooctene (TCO) |
| Molecular Formula | C88H166N2O42 |
| Molecular Weight | 1924.3 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TCO-PEG36-NHS Ester is a long chain, monodisperse PEG linker. The hydrophilic PEG36 spacer increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.
Chemical Information
Product Specification
Application
Computed Properties
| Purity | 95% |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[(4E)-cyclooct-4-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O |
| InChI | InChI=1S/C88H166N2O42/c91-85-8-9-86(92)90(85)132-87(93)10-12-95-14-16-97-18-20-99-22-24-101-26-28-103-30-32-105-34-36-107-38-40-109-42-44-111-46-48-113-50-52-115-54-56-117-58-60-119-62-64-121-66-68-123-70-72-125-74-76-127-78-80-129-82-83-130-81-79-128-77-75-126-73-71-124-69-67-122-65-63-120-61-59-118-57-55-116-53-51-114-49-47-112-45-43-110-41-39-108-37-35-106-33-31-104-29-27-102-25-23-100-21-19-98-17-15-96-13-11-89-88(94)131-84-6-4-2-1-3-5-7-84/h1-2,84H,3-83H2,(H,89,94)/b2-1+ |
| InChIKey | JGHVOJIUIMQLOY-OWOJBTEDSA-N |
| Solubility | DMSO, DCM, DMF |
| Storage | -20 °C |
TCO-PEG36-NHS ester, a versatile chemical pivotal in bioconjugation and molecular biology, finds diverse applications.
Antibody Labeling: Widely employed in biochemistry, TCO-PEG36-NHS ester acts as a crucial tool for covalently linking various tags and probes to antibodies. This strategic attachment allows researchers to monitor and visualize antibodies within intricate biological systems. Through the establishment of stable and specific conjugations, it amplifies the precision and sensitivity of immunodetection methods, opening new avenues for robust antibody analysis.
Drug Delivery Systems: At the frontier of pharmacology, TCO-PEG36-NHS ester plays a pivotal role in functionalizing drug carriers like nanoparticles with targeting moieties. This sophisticated modification enables the targeted delivery of therapeutic agents to specific cell populations or tissues, heralding a revolution in drug administration precision. By enhancing targeting efficiency, it not only boosts therapeutic efficacy but also mitigates adverse effects associated with drug delivery, paving the way for safer and more effective treatments.
Surface Modification: In the realm of biomedical engineering, TCO-PEG36-NHS ester is a sought-after agent for surface modification of biosensors and medical devices. Through its binding to surfaces, it mitigates nonspecific interactions and enhances biocompatibility, resulting in more accurate measurements and prolonged device functionality. This innovative approach not only elevates the precision of biosensing technologies but also extends the lifespan of medical devices, enhancing their utility in healthcare settings.
Click Chemistry: Positioned at the cutting edge of molecular biology, TCO-PEG36-NHS ester serves as a linchpin in bioorthogonal click chemistry reactions, a rapidly evolving field. Exhibiting selective reactivity with tetrazine-functionalized molecules, it facilitates the swift and precise assembly of intricate structures, revolutionizing molecular assembly processes.
| XLogP3 | -4.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 42 |
| Rotatable Bond Count | 115 |
| Exact Mass | 1923.0915173 g/mol |
| Monoisotopic Mass | 1923.0915173 g/mol |
| Topological Polar Surface Area | 434Ų |
| Heavy Atom Count | 132 |
| Formal Charge | 0 |
| Complexity | 2160 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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