TCO-PEG36-NHS ester

What We Offer

TCO-PEG36-NHS ester

TCO-PEG36-NHS ester

Catalog Number R15-0040
Category TCO
Molecular Formula C88H166N2O42
Molecular Weight 1924.3
Catalog Number Size Price Quantity
R15-0040 -- $--

Product Introduction

TCO-PEG36-NHS Ester is a long chain, monodisperse PEG linker. The hydrophilic PEG36 spacer increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

Chemical Information

Purity 95%
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[(4E)-cyclooct-4-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI InChI=1S/C88H166N2O42/c91-85-8-9-86(92)90(85)132-87(93)10-12-95-14-16-97-18-20-99-22-24-101-26-28-103-30-32-105-34-36-107-38-40-109-42-44-111-46-48-113-50-52-115-54-56-117-58-60-119-62-64-121-66-68-123-70-72-125-74-76-127-78-80-129-82-83-130-81-79-128-77-75-126-73-71-124-69-67-122-65-63-120-61-59-118-57-55-116-53-51-114-49-47-112-45-43-110-41-39-108-37-35-106-33-31-104-29-27-102-25-23-100-21-19-98-17-15-96-13-11-89-88(94)131-84-6-4-2-1-3-5-7-84/h1-2,84H,3-83H2,(H,89,94)/b2-1+
InChI Key JGHVOJIUIMQLOY-OWOJBTEDSA-N
Solubility DMSO, DCM, DMF
  • Product Specification
  • Application
Storage -20 °C

TCO-PEG36-NHS ester, a versatile chemical pivotal in bioconjugation and molecular biology, finds diverse applications.

Antibody Labeling: Widely employed in biochemistry, TCO-PEG36-NHS ester acts as a crucial tool for covalently linking various tags and probes to antibodies. This strategic attachment allows researchers to monitor and visualize antibodies within intricate biological systems. Through the establishment of stable and specific conjugations, it amplifies the precision and sensitivity of immunodetection methods, opening new avenues for robust antibody analysis.

Drug Delivery Systems: At the frontier of pharmacology, TCO-PEG36-NHS ester plays a pivotal role in functionalizing drug carriers like nanoparticles with targeting moieties. This sophisticated modification enables the targeted delivery of therapeutic agents to specific cell populations or tissues, heralding a revolution in drug administration precision. By enhancing targeting efficiency, it not only boosts therapeutic efficacy but also mitigates adverse effects associated with drug delivery, paving the way for safer and more effective treatments.

Surface Modification: In the realm of biomedical engineering, TCO-PEG36-NHS ester is a sought-after agent for surface modification of biosensors and medical devices. Through its binding to surfaces, it mitigates nonspecific interactions and enhances biocompatibility, resulting in more accurate measurements and prolonged device functionality. This innovative approach not only elevates the precision of biosensing technologies but also extends the lifespan of medical devices, enhancing their utility in healthcare settings.

Click Chemistry: Positioned at the cutting edge of molecular biology, TCO-PEG36-NHS ester serves as a linchpin in bioorthogonal click chemistry reactions, a rapidly evolving field. Exhibiting selective reactivity with tetrazine-functionalized molecules, it facilitates the swift and precise assembly of intricate structures, revolutionizing molecular assembly processes.

Computed Properties

XLogP3 -4.1
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 42
Rotatable Bond Count 115
Exact Mass 1923.0915173 g/mol
Monoisotopic Mass 1923.0915173 g/mol
Topological Polar Surface Area 434Ų
Heavy Atom Count 132
Formal Charge 0
Complexity 2160
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
cartIcon
Inquiry Basket