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(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate | CAS 1191901-33-3
| Catalog Number | R15-0047 |
| Category | Trans Cyclooctene (TCO) |
| Molecular Formula | C13H17NO5 |
| Molecular Weight | 267.28 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate is an ADC linker enabling strain-promoted click chemistry conjugation with antibodies. It facilitates rapid and stable payload attachment, improving antibody-drug conjugate targeting and therapeutic efficacy.
Chemical Information
Product Specification
Chemical Information
| Synonyms | TCO-NHS ester; TCO-NHS; (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate |
| Purity | 95% rel-(1R-4E-pR)-equatorial |
| IUPAC Name | [(4E)-cyclooct-4-en-1-yl] (2,5-dioxopyrrolidin-1-yl) carbonate |
| SMILES | C1CC=CCCC(C1)OC(=O)ON2C(=O)CCC2=O |
| InChI | InChI=1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+ |
| InChIKey | OUGQJOKGFAIFAQ-OWOJBTEDSA-N |
| Solubility | Soluble |
Product Specification
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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