TCO-PEG36-acid

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TCO-PEG36-acid

TCO-PEG36-acid

Catalog Number R15-0029
Category TCO
Molecular Formula C₈₄H₁₆₃NO₄₀
Molecular Weight 1827.18
Catalog Number Size Price Quantity
R15-0029 -- $--

Product Introduction

TCO-PEG36-acid is a polyethylene glycol (PEG)-based PROTAC linker. TCO-PEG36-acid can be used in the synthesis of a series of PROTACs.

Chemical Information

Purity 95%
IUPAC Name 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[(4Z)-cyclooct-4-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI InChI=1S/C84H163NO40/c86-83(87)8-10-89-12-14-91-16-18-93-20-22-95-24-26-97-28-30-99-32-34-101-36-38-103-40-42-105-44-46-107-48-50-109-52-54-111-56-58-113-60-62-115-64-66-117-68-70-119-72-74-121-76-78-123-80-81-124-79-77-122-75-73-120-71-69-118-67-65-116-63-61-114-59-57-112-55-53-110-51-49-108-47-45-106-43-41-104-39-37-102-35-33-100-31-29-98-27-25-96-23-21-94-19-17-92-15-13-90-11-9-85-84(88)125-82-6-4-2-1-3-5-7-82/h1-2,82H,3-81H2,(H,85,88)(H,86,87)/b2-1-
InChI Key XODRNEMODIMODD-UPHRSURJSA-N
Solubility DMSO, DMF, DCM
  • Product Specification
  • Application
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

TCO-PEG36-acid, a versatile bifunctional molecule, finds diverse applications in bioconjugation and drug delivery. Here are four key applications:

Drug Delivery Systems: Utilizing TCO-PEG36-acid, researchers can intricately link therapeutic agents to specific targeting molecules, elevating drug delivery precision and effectiveness. By tethering drugs to the TCO-PEG36-acid linker, controlled release mechanisms are enabled, leading to improved disease site targeting. This strategy not only optimizes drug bioavailability but also mitigates potential side effects, revolutionizing treatment outcomes.

Bioconjugation Techniques: In the realm of bioconjugation, TCO-PEG36-acid emerges as a pivotal linker for amalgamating diverse biomolecules. Its multifaceted nature facilitates the connection of various biochemical entities like enzymes, antibodies, and peptides, fostering the creation of multifunctional diagnostics and therapeutics. This capability opens new avenues for innovative biomedical applications, pushing the boundaries of research possibilities.

Biomedical Imaging: Within biomedical imaging, TCO-PEG36-acid plays an indispensable role in enhancing the visualization of biological processes within the body. By conjugating imaging agents with TCO-PEG36-acid, researchers achieve targeted delivery and prolonged circulation of imaging probes, heightening the sensitivity and resolution of imaging techniques such as MRI and PET scans. This advancement in imaging technology promises enhanced diagnostic capabilities and deeper insights into physiological phenomena.

Surface Modification: TCO-PEG36-acid’s utility extends to modifying the surface properties of nanoparticles and other delivery systems, bolstering particle stability, dispersibility, and biocompatibility. This surface adaptation enhances targeted delivery applications, particularly in fields like cancer therapy and immunotherapy. By leveraging TCO-PEG36-acid for surface functionalization, researchers can optimize the efficacy and specificity of therapeutic interventions, marking a significant stride in personalized medicine approaches.

Computed Properties

XLogP3 -3.6
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 40
Rotatable Bond Count 113
Exact Mass 1826.0751390 g/mol
Monoisotopic Mass 1826.0751390 g/mol
Topological Polar Surface Area 408Ų
Heavy Atom Count 125
Formal Charge 0
Complexity 1870
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
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