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Product Introduction
Propargyl-PEG8-amine is an alkyne-functionalized PEG linker used for copper-free click chemistry in ADC construction. The PEG8 spacer improves hydrophilicity and flexibility, facilitating bioorthogonal payload conjugation for improved antibody-drug conjugate stability.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms |
Propargyl-PEG8-amine; Propyne-PEG8-NH2 |
| Purity |
98.0% |
| Shelf Life |
0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name |
2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| Canonical SMILES |
C#CCOCCOCCOCCOCCOCCOCCOCCOCCN |
| InChI |
InChI=1S/C19H37NO8/c1-2-4-21-6-8-23-10-12-25-14-16-27-18-19-28-17-15-26-13-11-24-9-7-22-5-3-20/h1H,3-20H2 |
| InChIKey |
HJYYOUVXTIUMEJ-UHFFFAOYSA-N |
| Solubility |
10 mm in DMSO |
| Density |
1.1±0.1 g/cm3 |
| Appearance |
Solid powder |
| Boiling Point |
477.4±40.0 °C at 760 mmHg |
| Vapor Pressure |
0.0±1.2 mmHg at 25°C |
| LogP |
-2.61 |
| Storage |
Store at -5°C,keep in dry and avoid sunlight. |
| XLogP3 |
-1.8 |
| Hydrogen Bond Donor Count |
1 |
| Hydrogen Bond Acceptor Count |
9 |
| Rotatable Bond Count |
24 |
| Exact Mass |
407.25191714 g/mol |
| Monoisotopic Mass |
407.25191714 g/mol |
| Topological Polar Surface Area |
99.9Ų |
| Heavy Atom Count |
28 |
| Formal Charge |
0 |
| Complexity |
337 |
| Isotope Atom Count |
0 |
| Defined Atom Stereocenter Count |
0 |
| Undefined Atom Stereocenter Count |
0 |
| Defined Bond Stereocenter Count |
0 |
| Undefined Bond Stereocenter Count |
0 |
| Covalently-Bonded Unit Count |
1 |
| Compound Is Canonicalized |
Yes |
| Publication Number |
Title |
Priority Date |
| WO-2022272307-A1 |
Bifunctional folate receptor binding compounds |
2021-06-24 |
| WO-2022150721-A1 |
Bifunctional folate receptor binding compounds |
2021-01-08 |
| WO-2021050612-A1 |
Compositions and methods for the treatment of respiratory syncytial virus |
2019-09-09 |
| CA-3153626-A1 |
Compositions and methods for the treatment of respiratory syncytial virus |
2019-09-09 |
| CN-114728937-A |
Compositions and methods for treating respiratory syncytial virus |
2019-09-09 |
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