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Propargyl-PEG8-amine | CAS 1196732-52-1
| Catalog Number | R01-0202 |
| Category | Alkynes |
| Molecular Formula | C19H37NO8 |
| Molecular Weight | 407.50 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Propargyl-PEG8-amine is an alkyne-functionalized PEG linker used for copper-free click chemistry in ADC construction. The PEG8 spacer improves hydrophilicity and flexibility, facilitating bioorthogonal payload conjugation for improved antibody-drug conjugate stability.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | Propargyl-PEG8-amine; Propyne-PEG8-NH2 |
| Purity | 98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | 2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| Canonical SMILES | C#CCOCCOCCOCCOCCOCCOCCOCCOCCN |
| InChI | InChI=1S/C19H37NO8/c1-2-4-21-6-8-23-10-12-25-14-16-27-18-19-28-17-15-26-13-11-24-9-7-22-5-3-20/h1H,3-20H2 |
| InChIKey | HJYYOUVXTIUMEJ-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Density | 1.1±0.1 g/cm3 |
| Appearance | Solid powder |
| Boiling Point | 477.4±40.0 °C at 760 mmHg |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| LogP | -2.61 |
| Storage | Store at -5°C,keep in dry and avoid sunlight. |
| XLogP3 | -1.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 24 |
| Exact Mass | 407.25191714 g/mol |
| Monoisotopic Mass | 407.25191714 g/mol |
| Topological Polar Surface Area | 99.9Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 337 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022272307-A1 | Bifunctional folate receptor binding compounds | 2021-06-24 |
| WO-2022150721-A1 | Bifunctional folate receptor binding compounds | 2021-01-08 |
| WO-2021050612-A1 | Compositions and methods for the treatment of respiratory syncytial virus | 2019-09-09 |
| CA-3153626-A1 | Compositions and methods for the treatment of respiratory syncytial virus | 2019-09-09 |
| CN-114728937-A | Compositions and methods for treating respiratory syncytial virus | 2019-09-09 |
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