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Propargyl-PEG2-NHBoc | 869310-84-9
| Catelog Number | R01-0160 |
| Category | Alkynes |
| Molecular Formula | C12H21NO4 |
| Molecular Weight | 243.30 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0160 | -- | $-- |
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Product Introduction
Propargyl-PEG2-NHBoc is a crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper-catalyzed Click Chemistry reactions. The t-Boc-protected amine can be deprotected under mildly acidic conditions.
Chemical Information |
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|---|---|
| Related CAS | 1520979-34-3 (polymer) |
| Synonyms | t-Boc-N-Amido-PEG2-propargyl;t-Boc-N-Amido-PEG2-Propargyl; tert-Butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate; Boc-Amine-PEG2-propargyl; tert-butyl N-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl}carbamate; N-Boc-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine; 2-Methyl-2-propanyl {2-[2-(2-propyn-1-yloxy)ethoxy]ethyl}carbamate; Carbamic acid, N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester |
| Purity | ≥95% |
| Shelf Life | -20℃ 3 years powder; -80℃ 2 years in solvent |
| IUPAC Name | tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate |
| Canonical SMILES | CC(C)(C)OC(=O)NCCOCCOCC#C |
| InChI | InChI=1S/C12H21NO4/c1-5-7-15-9-10-16-8-6-13-11(14)17-12(2,3)4/h1H,6-10H2,2-4H3,(H,13,14) |
| InChI Key | WBOOWEAGRWGHMV-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO (10 mm) |
| Density | 1.0±0.1 g/cm3 |
| Appearance | Colorless to Light Yellow Liquid |
| Boiling Point | 344.2±27.0°C at 760 mmHg |
| LogP | 1.56840 |
Product Specification |
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|---|---|
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 0.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 243.14705815 g/mol |
| Monoisotopic Mass | 243.14705815 g/mol |
| Topological Polar Surface Area | 56.8Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 261 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022272133-A2 | Protein stabilizing compounds containing usp7 ligands | 2021-06-25 |
| WO-2022140472-A1 | Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway | 2020-12-22 |
| WO-2022125790-A1 | Irak degraders and uses thereof | 2020-12-09 |
| WO-2021188948-A1 | Mdm2 degraders and uses thereof | 2020-03-19 |
| WO-2020249969-A1 | Cgrp antagonist compounds | 2019-06-12 |
Applications of Fluorescent Probes & Dyes
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