3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol | CAS 1351556-81-4

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol is a long-chain propargylated poly(ethylene glycol)-type building block designed for copper-free and copper-mediated click chemistry workflows. As a terminal alkyne functionalized with an oligoether backbone, it combines high solubility and bioconjugation-friendly handle density with compatibility across common strain-promoted or CuAAC-compatible coupling strategies. This reagent is frequently used to introduce a robust clickable “PEG linker” motif into probes, surfaces, and biomaterials where spacer length, hydration, and conjugation flexibility are critical.

1. PEG Linker For Probes

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol is widely used as a click-ready PEG spacer for assembling fluorescent, affinity, and luminescent research probes that require controlled distance between a recognition element and a reporter. The extended oligoether chain helps maintain probe solubility and reduces nonspecific interactions during labeling and assay development, while the terminal alkyne provides a convenient coupling handle for downstream conjugation to azide-bearing dyes, targeting ligands, or detection tags. In molecular imaging and analytical chemistry workflows, this reagent is commonly selected to tune hydrodynamic behavior and improve compatibility with labeling buffers and surface-immobilized components.

2. Surface Functionalization Chemistry

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol supports the preparation of clickable coatings and functional surfaces used in biosensing, materials screening, and microarray fabrication. The PEG-rich chain can be used to create antifouling, hydration-stabilized interfaces, while the terminal alkyne enables post-assembly coupling to azide-modified biomolecules, nanoparticles, or capture reagents. Researchers and industrial R&D teams often employ this type of reagent when they need stable surface presentation of ligands with minimized steric crowding and improved reproducibility across batch-to-batch surface preparations.

3. Biomaterials And Hydrogel Labeling

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol is used to incorporate clickable PEG linkers into biomaterials and hydrogel systems for modular functionalization of polymer networks. By providing a flexible oligoether spacer terminating in an alkyne, the reagent enables subsequent attachment of bioactive moieties, imaging handles, or cell-interaction ligands through azide-functional partners. In biomaterials science, it is commonly integrated to adjust network swelling, hydration, and ligand accessibility, allowing researchers to generate material platforms where functional density and spatial presentation can be tuned by the choice of clickable counterpart.

4. Nanoparticle Conjugation Platforms

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol is applicable to the construction of nanoparticle and colloidal conjugates that require long, hydrophilic spacers between the particle surface and the attached functional group. The terminal alkyne serves as a reactive handle for click coupling to azide-bearing targeting ligands, tracking dyes, or affinity molecules, while the polyether backbone supports colloidal stability and reduces aggregation in formulation-relevant media. This reagent is frequently selected in chemical biology and diagnostics reagent development for creating modular nanoparticle labeling schemes where linker length and surface hydration strongly influence conjugate behavior during storage, mixing, and assay workflows.

5. Imaging And Diagnostics Reagent Building

3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol is used as a key building block for assembling imaging and diagnostic research reagents that rely on modular conjugation chemistry. The alkyne handle enables efficient incorporation of the PEG spacer into probe architectures, while the extended oligoether chain supports water compatibility and helps manage nonspecific background in complex assay environments. Teams developing molecular imaging reagents, affinity-based detection tools, and analytical labeling reagents often use this reagent to improve conjugate solubility and to provide a controllable linker length that supports reliable performance in downstream assay assembly and reagent handling.