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Propargyl-PEG2-acid | 1859379-85-3
| Catelog Number | R01-0220 |
| Category | Alkynes |
| Molecular Formula | C8H12O4 |
| Molecular Weight | 172.18 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R01-0220 | -- | $-- |
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Product Introduction
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information |
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|---|---|
| Synonyms | Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]- |
| Purity | ≥98.0% |
| Shelf Life | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| IUPAC Name | 3-(2-prop-2-ynoxyethoxy)propanoic acid |
| Canonical SMILES | C#CCOCCOCCC(=O)O |
| InChI | InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10) |
| InChI Key | NNWHATPXNWOQKD-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO |
| Density | 1.1±0.1 g/cm3 |
| Appearance | Pale Yellow Oily Matter |
| Boiling Point | 306.6±27.0°C at 760 mmHg |
Product Specification |
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|---|---|
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
| Signal | Danger |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| XLogP3 | -0.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 7 |
| Exact Mass | 172.07355886 g/mol |
| Monoisotopic Mass | 172.07355886 g/mol |
| Topological Polar Surface Area | 55.8Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 167 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022170155-A2 | Technologies for preventing or treating infections | 2021-02-06 |
| US-2017342211-A1 | Azlactone functionalized substrates for conjugation of biomolecules | 2016-05-31 |
| US-2012225089-A1 | Novel conjugates, preparation thereof, and therapeutic use thereof | 2009-06-29 |
| US-8952147-B2 | Conjugates, preparation thereof, and therapeutic use thereof | 2009-06-29 |
Applications of Fluorescent Probes & Dyes
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