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Propargyl-PEG2-acid | CAS 1859379-85-3
| Catalog Number | R01-0220 |
| Category | Alkynes |
| Molecular Formula | C8H12O4 |
| Molecular Weight | 172.18 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]- |
| Purity | ≥98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | 3-(2-prop-2-ynoxyethoxy)propanoic acid |
| Canonical SMILES | C#CCOCCOCCC(=O)O |
| InChI | InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10) |
| InChIKey | NNWHATPXNWOQKD-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO |
| Density | 1.1±0.1 g/cm3 |
| Appearance | Pale Yellow Oily Matter |
| Boiling Point | 306.6±27.0°C at 760 mmHg |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
| Signal | Danger |
| GHSHazardStatements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
Propargyl-PEG2-acid, a highly versatile chemical compound prized for its applications in bioconjugation and polymer modification, offers a myriad of possibilities. Here are four key applications of Propargyl-PEG2-acid presented with elevated levels of perplexity and burstiness:
Bioconjugation: Widely utilized in bioconjugation reactions, Propargyl-PEG2-acid plays a pivotal role in linking biomolecules like proteins, peptides, and antibodies. The unique propargyl group enables selective and efficient attachment through click chemistry, resulting in the creation of stable and biofunctional conjugates for diverse diagnostic and therapeutic purposes.
Drug Delivery Systems: In the realm of advanced drug delivery systems, Propargyl-PEG2-acid emerges as a crucial player in modifying drug carriers such as liposomes and nanoparticles. By augmenting the carriers' hydrophilicity and biocompatibility, it enhances drug solubility and circulation time in vivo, leading to more precise and efficient delivery of therapeutic agents to targeted diseased tissues.
Surface Modification: Embarking on the journey of surface modification, Propargyl-PEG2-acid finds its niche in altering various materials, including biomedical devices and implants. The PEGylation process facilitated by this compound imparts anti-fouling properties, curbing protein adsorption and cell adhesion. This transformative process may translate into enhanced biocompatibility and performance of medical implants and devices.
Chemical Biology: Within the realm of chemical biology, Propargyl-PEG2-acid emerges as a fundamental building block for synthesizing intricate molecules and probes. Its knack for participating in click reactions makes it an invaluable asset for tagging and tracking biological molecules within cells, enabling the meticulous study of molecular interactions and cellular processes in a highly specific and targeted manner.
| XLogP3 | -0.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 7 |
| Exact Mass | 172.07355886 g/mol |
| Monoisotopic Mass | 172.07355886 g/mol |
| Topological Polar Surface Area | 55.8Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 167 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022170155-A2 | Technologies for preventing or treating infections | 2021-02-06 |
| US-2017342211-A1 | Azlactone functionalized substrates for conjugation of biomolecules | 2016-05-31 |
| US-2012225089-A1 | Novel conjugates, preparation thereof, and therapeutic use thereof | 2009-06-29 |
| US-8952147-B2 | Conjugates, preparation thereof, and therapeutic use thereof | 2009-06-29 |
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