Propargyl-PEG2-acid

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Propargyl-PEG2-acid

Propargyl-PEG2-acid | 1859379-85-3

Catalog Number R01-0220
Category Alkynes
Molecular Formula C8H12O4
Molecular Weight 172.18
Catalog Number Size Price Quantity
R01-0220 -- $--

Product Introduction

Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Information

Synonyms Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-
Purity ≥98.0%
Shelf Life 0-4°C for short term (days to weeks), or -20°C for long term (months).
IUPAC Name 3-(2-prop-2-ynoxyethoxy)propanoic acid
Canonical SMILES C#CCOCCOCCC(=O)O
InChI InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)
InChI Key NNWHATPXNWOQKD-UHFFFAOYSA-N
Solubility Soluble in DMSO
Density 1.1±0.1 g/cm3
Appearance Pale Yellow Oily Matter
Boiling Point 306.6±27.0°C at 760 mmHg
  • Product Specification
  • Application
Storage Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Signal Danger
GHS Hazard Statements H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Propargyl-PEG2-acid, a highly versatile chemical compound prized for its applications in bioconjugation and polymer modification, offers a myriad of possibilities. Here are four key applications of Propargyl-PEG2-acid presented with elevated levels of perplexity and burstiness:

Bioconjugation: Widely utilized in bioconjugation reactions, Propargyl-PEG2-acid plays a pivotal role in linking biomolecules like proteins, peptides, and antibodies. The unique propargyl group enables selective and efficient attachment through click chemistry, resulting in the creation of stable and biofunctional conjugates for diverse diagnostic and therapeutic purposes.

Drug Delivery Systems: In the realm of advanced drug delivery systems, Propargyl-PEG2-acid emerges as a crucial player in modifying drug carriers such as liposomes and nanoparticles. By augmenting the carriers' hydrophilicity and biocompatibility, it enhances drug solubility and circulation time in vivo, leading to more precise and efficient delivery of therapeutic agents to targeted diseased tissues.

Surface Modification: Embarking on the journey of surface modification, Propargyl-PEG2-acid finds its niche in altering various materials, including biomedical devices and implants. The PEGylation process facilitated by this compound imparts anti-fouling properties, curbing protein adsorption and cell adhesion. This transformative process may translate into enhanced biocompatibility and performance of medical implants and devices.

Chemical Biology: Within the realm of chemical biology, Propargyl-PEG2-acid emerges as a fundamental building block for synthesizing intricate molecules and probes. Its knack for participating in click reactions makes it an invaluable asset for tagging and tracking biological molecules within cells, enabling the meticulous study of molecular interactions and cellular processes in a highly specific and targeted manner.

Computed Properties

XLogP3 -0.5
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 7
Exact Mass 172.07355886 g/mol
Monoisotopic Mass 172.07355886 g/mol
Topological Polar Surface Area 55.8Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 167
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2022170155-A2 Technologies for preventing or treating infections 2021-02-06
US-2017342211-A1 Azlactone functionalized substrates for conjugation of biomolecules 2016-05-31
US-2012225089-A1 Novel conjugates, preparation thereof, and therapeutic use thereof 2009-06-29
US-8952147-B2 Conjugates, preparation thereof, and therapeutic use thereof 2009-06-29
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