3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol | CAS 1036204-61-1

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol is a long, poly(ethylene glycol)-like alkyne-bearing building block designed for copper-free and copper-enabled click chemistry workflows, providing a hydrophilic spacer that improves solubility and reduces non-specific interactions. As a terminal propargyl alcohol derivative embedded in a repeating ether chain, it is commonly selected to introduce a reactive alkyne handle for modular conjugation strategies in chemical biology, biomaterials, and molecular imaging reagent development. Its extended, flexible structure makes it particularly useful when downstream conjugates require minimal steric hindrance and robust aqueous compatibility.

1. PEG Alkyne Surface Functionalization

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol is widely used to install an alkyne functional group on polymeric and colloidal surfaces where hydrophilic spacing is critical for maintaining colloidal stability and controlling surface reactivity. Researchers incorporate this reagent as a linker component in coating chemistries and surface modification pipelines, enabling subsequent conjugation to azide-bearing biomolecules, targeting ligands, or reporter tags. The ether-rich backbone helps mitigate aggregation and promotes uniform presentation of the clickable handle, which is valuable for building reproducible probe surfaces for microscopy, binding assays, and materials characterization.

2. Bioconjugation Linker For Probes

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol serves as a practical alkyne-bearing spacer for assembling multi-component bioconjugates, including affinity probes and labeling reagents used in chemical biology toolkits. The reagent’s long, flexible chain is commonly selected to reduce steric constraints between the reactive partner and the biological recognition element, supporting efficient downstream coupling to azide-functional constructs such as peptides, carbohydrates, or nucleic-acid analogs. Because it provides an additional hydrophilic domain, it is frequently chosen when probe performance depends on maintaining solubility under labeling and wash conditions used in laboratory workflows.

3. Molecular Imaging And Reporter Assembly

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol is used in the synthesis of modular imaging and detection reagents where an alkyne handle must be appended to a hydrophilic scaffold prior to attaching fluorophores, affinity tags, or other signal-bearing moieties. The extended ether chain helps tune the overall hydrophilicity and can improve handling and conjugate stability during reagent preparation and purification. In molecular imaging workflows, this reagent is often selected to create conjugates with controlled spacing between the reporter and the binding unit, supporting consistent labeling density and reducing aggregation that can complicate optical readouts and probe characterization.

4. Hydrogel And Biomaterial Crosslinking

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol is applied as an alkyne-functional modifier in biomaterials development, particularly when hydrophilic linkers are needed to tailor gel formation, swelling behavior, and network accessibility. Materials scientists use it to introduce clickable sites into polymer matrices and hydrogel formulations, enabling post-fabrication coupling to azide-functional crosslinkers, bioactive peptides, or cell-interactive motifs. The ether-rich spacer can contribute to reduced non-specific adsorption and improved aqueous compatibility, which supports reproducible material performance across iterative prototyping and characterization cycles.

5. Diagnostic Reagent Platform Building

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol is incorporated into diagnostic reagent development pipelines that rely on modular conjugation of capture and reporting components. By providing a terminal alkyne within a highly water-compatible chain, it enables robust coupling to azide-functional assay elements such as affinity reagents, polymeric reporters, or surface-anchored detection constructs. Teams developing assay reagents often favor this type of spacer to manage steric effects and improve reagent handling in buffered systems, supporting consistent conjugate assembly for downstream assay optimization and analytical validation.