![{[Name]}](https://resource.bocsci.com/structure/82909-47-5.gif?v=2025011501)
![{[Name]}](https://resource.bocsci.com/structure/40842-04-4.gif?v=2025011501)
![{[Name]}](https://resource.bocsci.com/structure/1036204-61-1.gif?v=2025011501)
![{[Name]}](https://resource.bocsci.com/structure/944560-99-0.gif?v=2025011501)
![{[Name]}](https://resource.bocsci.com/structure/1351556-81-4.gif?v=2025011501)
![{[Name]}](https://resource.bocsci.com/structure/99208-90-9.gif?v=2025011501)
Inquiry Basket
Propargyl-PEG5-NHS ester | CAS 1393330-40-9
| Catalog Number | R01-0227 |
| Category | Alkynes |
| Molecular Formula | C18H27NO9 |
| Molecular Weight | 401.41 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Alkyne-PEG5-NHS;Alkyne-PEG5-N-hydroxysuccinimidyl ester; 2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16-pentaoxanonadec-18-yn-1-oate |
| Purity | >98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C#CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
| InChI | InChI=1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2 |
| InChIKey | ACZDUKRWTPZVRP-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Density | 1.2±0.1 g/cm3 |
| Appearance | Light yellow to brown clear liquid |
| Boiling Point | 497.6±55.0 °C at 760 mmHg |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
| LogP | -2.68 |
| Storage | Store at 4 °C |
Propargyl-PEG5-NHS ester, a versatile reagent utilized in biochemical and medical research, for diverse applications. Behold, presented with heightened perplexity and burstiness, are four key applications of Propargyl-PEG5-NHS ester:
Bioconjugation: Acting as a linchpin in bioconjugation practices, Propargyl-PEG5-NHS ester finds extensive utility in forging stable covalent connections between biomolecules. Through interaction with amine groups on proteins, peptides, or other entities, it engenders durable conjugates. This capability facilitates precision delivery of therapeutics and the construction of intricate diagnostic instruments.
Drug Delivery: Within the realm of drug delivery mechanisms, Propargyl-PEG5-NHS ester serves as a transformative tool for augmenting the solubility, stability, and bioavailability of drug molecules or delivery carriers. By affixing PEG chains, it elevates the pharmacokinetic attributes of drugs, leading to prolonged circulation periods and diminished immunogenic responses.
Surface Functionalization: Playing a pivotal role in surface functionalization endeavors, Propargyl-PEG5-NHS ester is harnessed to modify the exteriors of nanoparticles, medical apparatus, and assorted biomaterials. The process of PEGylation bestows biocompatibility while curbing protein absorption and cellular adhesion. Such functionality proves critical in scenarios like implantable devices and targeted dispensation platforms.
Click Chemistry: Exploiting the alkyne moiety in Propargyl-PEG5-NHS ester, click chemistry methodologies, particularly in the realm of bioorthogonal labeling, are significantly enhanced. Coupled with azide-functionalized molecules, it facilitates the formation of stable triazoles, enabling efficient and specific conjugations.
| XLogP3 | -1.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 18 |
| Exact Mass | 401.16858144 g/mol |
| Monoisotopic Mass | 401.16858144 g/mol |
| Topological Polar Surface Area | 110Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 512 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022056273-A1 | Lipid conjugates for the delivery of therapeutic agents | 2020-09-11 |
| US-2022017471-A1 | Functionality independent labeling of organic compounds | 2018-07-18 |
| US-2017362266-A1 | Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions | 2016-06-15 |
| US-10620217-B2 | Proximity assays using chemical ligation and hapten transfer | 2014-11-25 |
| US-2017254813-A1 | Proximity assays using chemical ligation and hapten transfer | 2014-11-25 |
Recommended Services
Recommended Articles
- Hoechst Dyes: Definition, Structure, Mechanism and Applications
- Mastering the Spectrum: A Comprehensive Guide to Cy3 and Cy5 Dyes
- Fluorescent Probes: Definition, Structure, Types and Application
- Fluorescent Dyes: Definition, Mechanism, Types and Application
- Coumarin Dyes: Definition, Structure, Benefits, Synthesis and Uses
- BODIPY Dyes: Definition, Structure, Synthesis and Uses
- Cyanine Dyes: Definition, Structure, Types and Uses
- Fluorescein Dyes: Definition, Structure, Synthesis and Uses
- Rhodamine Dyes: Definition, Structure, Uses, Excitation and Emission
- Unlocking the Power of Fluorescence Imaging: A Comprehensive Guide
- Cell Imaging: Definitions, Systems, Protocols, Dyes, and Applications
- Lipid Staining: Definition, Principles, Methods, Dyes, and Uses
- Flow Cytometry: Definition, Principles, Protocols, Dyes, and Uses
- Nucleic Acid Staining: Definition, Principles, Dyes, Procedures, and Uses
- DNA Staining: Definition, Procedures, Benefits, Dyes and Uses
- Cell Staining: Definition, Principles, Protocols, Dyes, and Uses
- Ion Imaging: Definition, Principles, Benefits, Dyes, and Uses
- Fluorescent Labeling: Definition, Principles, Types and Applications
Recommended Products
Online Inquiry
