Propargyl-PEG3-NHS ester

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Propargyl-PEG3-NHS ester

Propargyl-PEG3-NHS ester | 1428629-71-3

Catalog Number R01-0229
Category Alkynes
Molecular Formula C14H19NO7
Molecular Weight 313.30
Catalog Number Size Price Quantity
R01-0229 -- $--

Chemical Information

Synonyms Alkyne-PEG3-NHS;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
Purity >98.0%
Shelf Life 0-4°C for short term (days to weeks), or -20°C for long term (months).
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate
Canonical SMILES C#CCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChI InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChI Key YDRPXORAOIYIGV-UHFFFAOYSA-N
Solubility 10 mm in DMSO
Density 1.3±0.1 g/cm3
Appearance Transparent Liquid
Boiling Point 427.2±55.0 °C at 760 mmHg
Vapor Pressure 0.0±1.0 mmHg at 25°C
LogP -1.96
  • Product Specification
  • Application
Excitation 647
Emission 655
Storage Store at -20 °C, keep in dry and avoid sunlight.

Propargyl-PEG3-NHS ester, a versatile chemical reagent widely utilized in bioconjugation, presents myriad applications. Here are four key applications showcased with elevated perplexity and burstiness.

Protein Labeling: Employing Propargyl-PEG3-NHS ester for protein labeling involves a sophisticated process of reacting with primary amines on lysine residues to facilitate the covalent attachment of fluorescent dyes or other tags. This intricate procedure enables researchers to delve into protein localization, interactions, and dynamics across diverse biological systems with utmost precision and detail.

Bioorthogonal Chemistry: The alkyne group within Propargyl-PEG3-NHS ester lends itself to bioorthogonal labeling via click chemistry, a cutting-edge technique in molecular biology. Scientists leverage copper-catalyzed azide-alkyne cycloaddition to selectively conjugate biomolecules under physiological conditions, enabling the tracking and visualization of molecules within live cells without disrupting native biological processes.

Drug Delivery Systems: In the realm of drug delivery, Propargyl-PEG3-NHS ester plays a pivotal role in modifying delivery vehicles like nanoparticles or liposomes with targeting ligands or therapeutic agents. By introducing propargyl groups on the surface, these carriers can be intricately conjugated with azide-containing molecules, enhancing the specificity and efficiency of drug delivery to precise tissues or cells. This strategic approach holds immense promise in advancing targeted drug delivery systems for enhanced therapeutic outcomes.

Surface Modification: Beyond its conventional applications, Propargyl-PEG3-NHS ester finds utility in surface modification for biosensors, microarrays, and diagnostic platforms, ushering in a new era of precision in bioanalytics. Through coupling this reagent to amine-functionalized surfaces, researchers can attach an array of biomolecules for detection purposes, elevating the sensitivity and specificity of diagnostic assays to unprecedented levels.

Computed Properties

XLogP3 -1.2
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 12
Exact Mass 313.11615195 g/mol
Monoisotopic Mass 313.11615195 g/mol
Topological Polar Surface Area 91.4Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 424
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
EP-4087584-A2 Cell surface receptor binding compounds and conjugates 2020-01-10
WO-2021067738-A1 Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters 2019-10-04
EP-4037691-A1 Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters 2019-10-04
US-2019328900-A1 Antibody-drug conjugates and therapeutic methods using the same 2016-07-01
US-2019142906-A1 Insulin receptor partial agonists and glp-1 analogues 2016-05-24
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