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Propargyl-PEG3-NHS ester | CAS 1428629-71-3
| Catalog Number | R01-0229 |
| Category | Alkynes |
| Molecular Formula | C14H19NO7 |
| Molecular Weight | 313.30 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | Alkyne-PEG3-NHS;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate |
| Purity | >98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate |
| Canonical SMILES | C#CCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
| InChI | InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2 |
| InChIKey | YDRPXORAOIYIGV-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Density | 1.3±0.1 g/cm3 |
| Appearance | Transparent Liquid |
| Boiling Point | 427.2±55.0 °C at 760 mmHg |
| Vapor Pressure | 0.0±1.0 mmHg at 25°C |
| LogP | -1.96 |
| Excitation | 647 |
| Emission | 655 |
| Storage | Store at -20 °C, keep in dry and avoid sunlight. |
Propargyl-PEG3-NHS ester, a versatile chemical reagent widely utilized in bioconjugation, presents myriad applications. Here are four key applications showcased with elevated perplexity and burstiness.
Protein Labeling: Employing Propargyl-PEG3-NHS ester for protein labeling involves a sophisticated process of reacting with primary amines on lysine residues to facilitate the covalent attachment of fluorescent dyes or other tags. This intricate procedure enables researchers to delve into protein localization, interactions, and dynamics across diverse biological systems with utmost precision and detail.
Bioorthogonal Chemistry: The alkyne group within Propargyl-PEG3-NHS ester lends itself to bioorthogonal labeling via click chemistry, a cutting-edge technique in molecular biology. Scientists leverage copper-catalyzed azide-alkyne cycloaddition to selectively conjugate biomolecules under physiological conditions, enabling the tracking and visualization of molecules within live cells without disrupting native biological processes.
Drug Delivery Systems: In the realm of drug delivery, Propargyl-PEG3-NHS ester plays a pivotal role in modifying delivery vehicles like nanoparticles or liposomes with targeting ligands or therapeutic agents. By introducing propargyl groups on the surface, these carriers can be intricately conjugated with azide-containing molecules, enhancing the specificity and efficiency of drug delivery to precise tissues or cells. This strategic approach holds immense promise in advancing targeted drug delivery systems for enhanced therapeutic outcomes.
Surface Modification: Beyond its conventional applications, Propargyl-PEG3-NHS ester finds utility in surface modification for biosensors, microarrays, and diagnostic platforms, ushering in a new era of precision in bioanalytics. Through coupling this reagent to amine-functionalized surfaces, researchers can attach an array of biomolecules for detection purposes, elevating the sensitivity and specificity of diagnostic assays to unprecedented levels.
| XLogP3 | -1.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 12 |
| Exact Mass | 313.11615195 g/mol |
| Monoisotopic Mass | 313.11615195 g/mol |
| Topological Polar Surface Area | 91.4Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 424 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-4087584-A2 | Cell surface receptor binding compounds and conjugates | 2020-01-10 |
| WO-2021067738-A1 | Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters | 2019-10-04 |
| EP-4037691-A1 | Development of imaging and therapeutic glucose analogues for sodium dependent glucose transporters | 2019-10-04 |
| US-2019328900-A1 | Antibody-drug conjugates and therapeutic methods using the same | 2016-07-01 |
| US-2019142906-A1 | Insulin receptor partial agonists and glp-1 analogues | 2016-05-24 |
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