3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol | CAS 1422023-54-8

3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol is a long-chain propargyl alcohol featuring a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) and a densely oxygenated oligoether segment that improves solubility and bioconjugation compatibility. Its extended, flexible scaffold is commonly selected when an alkyne handle must be presented with reduced steric interference from surrounding biomolecules or surfaces. As a click-ready linker component, it is widely used to build azide-reactive conjugates for materials functionalization, probe labeling, and molecular imaging reagent development.

1. Surface And Material Functionalization

3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol is used to introduce a stable alkyne functionality onto polymeric, nanoparticle, and membrane-like platforms prior to azide-based coupling. The oligoether-rich chain helps maintain colloidal stability and reduces nonspecific interactions during downstream conjugation workflows, which is valuable for preparing functional coatings, biointerfaces, and assay-compatible materials. After azide installation on the target ligand or capture element, CuAAC enables robust attachment of the alkyne-bearing surface component to generate reproducible, spatially addressable functional materials for research and industrial R&D.

2. Biomolecule Labeling Workflows

3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol supports click-based labeling strategies where an alkyne handle is required for subsequent conjugation to azide-tagged proteins, peptides, glycans, or nucleic-acid reagents. The long oligoether spacer can reduce steric hindrance, helping maintain accessibility of the reactive alkyne during conjugate formation and improving labeling uniformity in multi-step workflows. Researchers commonly incorporate this reagent into reagent kits and intermediate building blocks to streamline the preparation of azide-reactive imaging probes, affinity reagents, and analytical standards.

3. Molecular Imaging Probe Construction

3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol is frequently employed as a click-compatible linker for assembling imaging and detection probes that require controlled presentation of a reactive handle. The propargyl alcohol motif provides a convenient alkyne endpoint for CuAAC coupling to azide-functional imaging moieties, while the oxygenated tether supports favorable solvation and reduces aggregation of probe constructs during formulation and handling. This makes the reagent useful for generating modular probe libraries in chemical biology and molecular imaging development, where consistent conjugation chemistry and flexible spacing are important for reproducible probe performance in assays.

4. Diagnostic Reagent And Assay Builds

3,6,9,12,15,18,21-Heptaoxatetracos-23-yn-1-ol is applied in the construction of assay reagents that rely on azide–alkyne click coupling to attach recognition elements, reporters, or immobilization handles. Its long, ether-rich scaffold is advantageous when conjugation must occur without compromising binding-site accessibility or when the resulting conjugates need improved handling in aqueous assay buffers. In diagnostic reagent development workflows, this reagent is commonly used as an intermediate to generate clickable reporter conjugates and surface-tethered components that can be combined with azide-bearing partners to produce consistent assay formats for research-grade testing.