Propargyl-PEG5-amine | 1589522-46-2
Catelog Number | R01-0204 |
Category | Alkynes |
Molecular Formula | C13H25NO5 |
Molecular Weight | 275.34 |
Catalog Number | Size | Price | Quantity |
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R01-0204 | -- | $-- |
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Product Introduction
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Chemical Information |
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Synonyms | Propargyl-PEG5-NH2 |
Purity | >98.0% |
Shelf Life | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
IUPAC Name | 2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine |
Canonical SMILES | C#CCOCCOCCOCCOCCOCCN |
InChI | InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2 |
InChI Key | BLBTXXAWMPTQOK-UHFFFAOYSA-N |
Solubility | 10 mm in DMSO |
Density | 1.0±0.1 g/cm3 |
Appearance | Colorless Liquid |
Boiling Point | 360.4±37.0 °C at 760 mmHg |
Vapor Pressure | 0.0±0.8 mmHg at 25°C |
LogP | -1.54 |
Product Specification |
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Storage | Store at -5°C,keep in dry and avoid sunlight. |
Computed Properties | |
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XLogP3 | -1.3 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 15 |
Exact Mass | 275.17327290 g/mol |
Monoisotopic Mass | 275.17327290 g/mol |
Topological Polar Surface Area | 72.2Ų |
Heavy Atom Count | 19 |
Formal Charge | 0 |
Complexity | 216 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
Patents
Publication Number | Title | Priority Date |
---|---|---|
WO-2020152067-A1 | Heterocyclic derivatives | 2019-01-22 |
US-2022062258-A1 | Heterocyclic derivatives | 2019-01-22 |
US-2018346457-A1 | Raf-degrading conjugate compounds | 2017-04-28 |
US-10787443-B2 | RAF-degrading conjugate compounds | 2017-04-28 |
US-2018207276-A1 | Modified therapeutic agents and compositions thereof | 2015-03-18 |
Applications of Fluorescent Probes & Dyes
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