Propargyl-PEG5-amine | 1589522-46-2

Catelog Number	R01-0204
Category	Alkynes
Molecular Formula	C13H25NO5
Molecular Weight	275.34

Catalog Number	Size	Price	Quantity
R01-0204	--	$--

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Product Introduction

Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Chemical Information
Synonyms	Propargyl-PEG5-NH2
Purity	>98.0%
Shelf Life	0-4℃ for short term (days to weeks), or -20℃ for long term (months).
IUPAC Name	2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES	C#CCOCCOCCOCCOCCOCCN
InChI	InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2
InChI Key	BLBTXXAWMPTQOK-UHFFFAOYSA-N
Solubility	10 mm in DMSO
Density	1.0±0.1 g/cm3
Appearance	Colorless Liquid
Boiling Point	360.4±37.0 °C at 760 mmHg
Vapor Pressure	0.0±0.8 mmHg at 25°C
LogP	-1.54

Product Specification
Storage	Store at -5°C,keep in dry and avoid sunlight.

Computed Properties
XLogP3	-1.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Exact Mass	275.17327290 g/mol
Monoisotopic Mass	275.17327290 g/mol
Topological Polar Surface Area	72.2Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	216
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
WO-2020152067-A1	Heterocyclic derivatives	2019-01-22
US-2022062258-A1	Heterocyclic derivatives	2019-01-22
US-2018346457-A1	Raf-degrading conjugate compounds	2017-04-28
US-10787443-B2	RAF-degrading conjugate compounds	2017-04-28
US-2018207276-A1	Modified therapeutic agents and compositions thereof	2015-03-18

Applications of Fluorescent Probes & Dyes

Laser Dye

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Propargyl-PEG5-amine | 1589522-46-2

Product Introduction

Chemical Information

Product Specification

Computed Properties

Patents