Propargyl-PEG2-methylamine | 1835759-76-6

Catelog Number	R01-0120
Category	Alkynes
Molecular Formula	C8H15NO2
Molecular Weight	157.2

Catalog Number	Size	Price	Quantity
R01-0120	--	$--

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Product Introduction

Propargyl-PEG2-methylamine is a crosslinker with a propargyl group and methylamine group. The propargyl group forms triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Chemical Information
Synonyms	N-methyl-2-(2-prop-2-ynoxyethoxy)ethanamine; Propargyl-PEG2-NHMe; Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]- methyl({2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl})amine
Purity	98%
IUPAC Name	N-methyl-2-(2-prop-2-ynoxyethoxy)ethanamine
Canonical SMILES	CNCCOCCOCC#C
InChI	InChI=1S/C8H15NO2/c1-3-5-10-7-8-11-6-4-9-2/h1,9H,4-8H2,2H3
InChI Key	XZTAFUAQYHXUMA-UHFFFAOYSA-N
Solubility	Water, DMSO, DCM, DMF

Product Specification
Storage	-20 °C

Computed Properties
XLogP3	-0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
Exact Mass	157.110278721 g/mol
Monoisotopic Mass	157.110278721 g/mol
Topological Polar Surface Area	30.5Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	117
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
WO-2021260438-A1	Antibody-drug conjugates comprising anti-b7-h3 antibodies	2020-06-26
US-2012269766-A1	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus	2009-10-13
US-2016082102-A1	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus	2009-10-13
US-9181224-B2	Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus	2009-10-13
US-2012034295-A1	Chimeric small molecules for the recruitment of antibodies to cancer cells	2008-05-13