m-PEG17-propargyl | CAS 146185-77-5

m-PEG17-propargyl is a methoxy-terminated polyethylene glycol (PEG) click handle bearing a terminal propargyl group, designed for copper-free or copper-catalyzed alkyne-based bioconjugation workflows. As a PEGylated propargyl reagent, it combines the steric and solubility benefits of long-chain PEG with a reactive alkyne for click chemistry functionalization of biomolecules, surfaces, and materials. This reagent is commonly used to install PEG spacers onto targets such as proteins, peptides, polymers, and nanoparticles, supporting improved stability, reduced nonspecific interactions, and controlled surface/bioconjugate architecture for downstream research and industrial development.

1. PEGylation Of Biomolecules

m-PEG17-propargyl is widely used to introduce a long PEG spacer onto proteins, peptides, or peptide-like ligands via alkyne click coupling to complementary azide-bearing partners. Researchers employ this reagent to tune hydrodynamic size, modulate surface charge presentation, and improve colloidal stability of conjugates used in chemical biology and biomaterials research. The PEG length and terminal alkyne functionality make it a practical building block for generating well-defined PEGylated bioconjugates for assay development, probe construction, and platform optimization.

2. Surface Functionalization For Materials

m-PEG17-propargyl is used to functionalize polymeric and inorganic material surfaces where PEG chains are needed to control wettability, reduce fouling, and improve biocompatible interface behavior in research-grade materials. The propargyl group enables click-based attachment to azide-functionalized coatings, membranes, or scaffold surfaces, allowing consistent installation of PEG layers without relying on harsh coupling chemistries. This application is common in interface engineering, coating development, and the creation of anti-nonspecific environments for immobilized reagents and imaging handles.

3. Nanoparticle And Colloidal Conjugates

m-PEG17-propargyl serves as a PEG–alkyne linker for decorating nanoparticles and colloidal carriers with defined clickable functionality. In molecular imaging and diagnostic reagent development workflows, PEGylation is frequently used to improve dispersion stability and minimize aggregation, while the terminal alkyne provides a modular handle for subsequent conjugation to azide-tagged targeting motifs, reporter components, or capture ligands. The reagent’s PEG chain length supports formation of robust steric layers that help maintain colloidal integrity during multi-step labeling and formulation.

4. Linker For Multi-Step Probe Assembly

m-PEG17-propargyl is commonly incorporated as a modular PEG spacer in multi-component probe assembly, where orthogonal or sequential click steps are used to build complex conjugates. Chemical biology groups use the propargyl handle to connect PEGylated segments to azide-functional reporters, affinity tags, or scaffold molecules, enabling flexible design of probe architectures with controlled spacing between functional moieties. This approach is particularly useful when long-range steric separation is required to preserve binding accessibility, reduce background interactions, or improve performance of immobilized or solution-phase labeling reagents.