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endo-BCN-PEG2-PFP ester | CAS 1421932-53-7
| Catalog Number | R16-0020 |
| Category | BCN Reagents |
| Molecular Formula | C24H26F5NO6 |
| Molecular Weight | 519.46 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | perfluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oate; |
| Purity | ≥98% |
| IUPAC Name | |
| Canonical SMILES | C1CC2C(C2COC(=O)NCCOCCOCCC(=O)OC3=C(C(=C(C(=C3F)F)F)F)F)CCC#C1 |
| InChI | InChI=1S/C24H26F5NO6/c25-18-19(26)21(28)23(22(29)20(18)27)36-17(31)7-9-33-11-12-34-10-8-30-24(32)35-13-16-14-5-3-1-2-4-6-15(14)16/h14-16H,3-13H2,(H,30,32) |
| InChIKey | OQSLFTLVSWOAIW-UHFFFAOYSA-N |
| Solubility | DMSO, DCM, DMF |
| Appearance | Soild powder |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Endo-BCN-PEG2-PFP ester, a highly reactive chemical linker essential for bioconjugation and labeling, finds diverse applications in biotechnology.
Site-Specific Bioconjugation: Emerging as a pioneering force in the realm of bioconjugation, endo-BCN-PEG2-PFP ester assumes a crucial role in facilitating the selective attachment of biomolecules, such as peptides, proteins, or antibodies, to a myriad of surfaces or entities. Its unparalleled reactivity towards strained alkynes, harnessed through copper-free click chemistry, ensures a precise and efficient conjugation process. This unique capacity proves particularly invaluable for crafting uniform bioconjugates customized for therapeutic and diagnostic purposes.
Drug Delivery Systems: Spearheading innovation in drug delivery, this ester stands as a revolutionary catalyst, driving the creation of sophisticated systems aimed at enhancing the pharmacokinetics and bioavailability of therapeutic agents through PEGylation. Endo-BCN-PEG2-PFP ester enables the stable and specific attachment of PEG chains to drugs or carriers, thereby improving solubility, reducing immunogenicity, and prolonging circulation time in the body. This groundbreaking methodology holds the potential to redefine drug administration practices.
Immunoassay Development: Serving as an indispensable asset in the progression of immunoassays, endo-BCN-PEG2-PFP ester fuels the development of sensitive assays tailored for detecting specific biomolecules. By conjugating antigens or antibodies to solid supports or reporter molecules, this ester contributes to the creation of highly specific and sensitive immunoassays essential for clinical diagnostics, research, and disease surveillance. Its adaptability and precision position it as a cornerstone in the evolutionary trajectory of immunoassay technologies.
Surface Modification: Delving into the realm of sophisticated surface engineering, this ester catalyzes the transformation of medical devices, nanoparticles, and biosensors, enhancing their biocompatibility and functionality. Leveraging endo-BCN-PEG2-PFP ester for attaching biomolecules or polymers enables the meticulous adjustment of surface properties, including antifouling characteristics, cell adhesion capabilities, and biospecific interactions. This strategic modification serves as a pivotal advancement in biomedical device development, optimizing their performance across diverse clinical scenarios and showcasing the transformative capabilities of surface engineering in biotechnology.
| XLogP3 | 3.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 14 |
| Exact Mass | 519.16802836 g/mol |
| Monoisotopic Mass | 519.16802836 g/mol |
| Topological Polar Surface Area | 83.1Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 772 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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