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BCN (R)-Glycerol Phosphoramidite
| Catalog Number | R10-0043 |
| Category | BCN Reagents |
| Molecular Formula | C53H74N3O11P |
| Molecular Weight | 960.16 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
BCN (R)-Glycerol Phosphoramidite is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a phosphoramidite moiety via an (R)-glycerol linker. The (R)-glycerol linker provides a chiral, hydrophilic scaffold, while the BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.
Chemical Information
Chemical Information
| Synonyms | BCN TEG (DMT) (R)-Glycerol Phosphoramidite; BCN TEG (DMT) Phosphoramidite (R); ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((4R)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-18-yl)carbamate |
| SMILES | CC(N(P(O[C@H](COCCOCCOCCOCCCNC(OC[C@@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H])=O)COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)OCCC#N)C(C)C)C |
| InChI | InChI=1S/C53H74N3O11P/c1-41(2)56(42(3)4)68(66-31-14-28-54)67-48(39-65-53(43-16-10-9-11-17-43,44-20-24-46(58-5)25-21-44)45-22-26-47(59-6)27-23-45)38-63-37-36-62-35-34-61-33-32-60-30-15-29-55-52(57)64-40-51-49-18-12-7-8-13-19-50(49)51/h9-11,16-17,20-27,41-42,48-51H,12-15,18-19,29-40H2,1-6H3,(H,55,57)/t48-,49-,50+,51+,68?/m1/s1 |
| InChIKey | OXGJDLMEDKZGOC-VJTXMCHVSA-N |
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