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BCN-PEG5-amine (endo)
| Catalog Number | R16-0032 |
| Category | BCN Reagents |
| Molecular Formula | C23H40N2O7 |
| Molecular Weight | 456.57 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
A heterobifunctional BCN linker with carboxylic acid reactivity
Chemical Information
Product Specification
Application
| Purity | >90% |
| Solubility | DCM, THF, Acetonitrile, DMF and DMSO |
| Appearance | Colorless oil |
| Storage | -20 °C |
BCN-PEG5-amine (endo), a multifaceted crosslinker that merges a BCN (bicyclo[6.1.0]non-4-yne) entity, a PEG5 (polyethylene glycol) spacer, and an amine group, exhibits a myriad of applications in biotechnology.
Bioconjugation: Serving as a cornerstone in bioconjugation strategies, BCN-PEG5-amine (endo) assumes a pivotal role in facilitating the linkage of biomolecules ranging from proteins to peptides to antibodies. The BCN moiety engages in interactions with azide-tagged entities through strain-promoted azide-alkyne cycloaddition (SPAAC), negating the necessity for a catalyst. These interactions yield enduring covalent conjugates, ideal for utilization in diagnostics, therapeutics, and avant-garde research pursuits.
Drug Delivery: By leveraging the amphiphilic characteristics of the PEG5 spacer within BCN-PEG5-amine (endo), enhanced solubility and reduced immunogenicity of drug compounds come to the forefront. This compound enables the attachment of therapeutic agents to targeting ligands, enhancing drug delivery precision and efficacy. BCN-PEG5-amine (endo) emerges as a prized asset in the domain of targeted drug delivery systems, exemplified by sophisticated antibody-drug conjugates that reshape the therapeutic landscape.
Surface Modification: Positioned as a versatile tool for surface modifications of biomaterials, BCN-PEG5-amine (endo) elevates biocompatibility and functionality. By tethering the amine group to diverse substrates, the integration of PEGylated surfaces resistant to protein adsorption and cell adhesion materializes. This application stands as a pivotal element in the progression of medical implants, biosensors, and tissue engineering scaffolds.
Molecular Imaging: Stepping into the realm of molecular imaging, BCN-PEG5-amine (endo) facilitates the conjugation of imaging agents to biomolecular targets. The flexible PEG spacer navigates steric hindrances to ensure seamless binding of imaging probes to designated molecules. This capability is invaluable for crafting targeted imaging agents for modalities such as PET, MRI, and fluorescence imaging, enabling precise visualization of intricate biological processes.
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