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Dihydrorhodamine 123 | CAS 109244-58-8
| Catalog Number | A03-0012 |
| Category | NO & ROS Probes |
| Molecular Formula | C21H18N2O3 |
| Molecular Weight | 346.4 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Dihydrorhodamine 123 is a non-fluorescent ROS indicator that becomes fluorescent upon oxidation. It’s perfect for detecting reactive oxygen species and oxidative stress in biological samples.
Chemical Information
Product Specification
Computed Properties
Literatures
Patents
| Synonyms | DHR 123; 2-(3,6-diamino-9H-xanthen-9-yl)-benzoic acid methyl ester |
| Purity | ≥98% |
| IUPAC Name | methyl 2-(3,6-diamino-9H-xanthen-9-yl)benzoate |
| Canonical SMILES | COC(=O)C1=CC=CC=C1C2C3=C(C=C(C=C3)N)OC4=C2C=CC(=C4)N |
| InChI | InChI=1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3 |
| InChIKey | FNEZBBILNYNQGC-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO |
| Appearance | Solid Powder |
| Excitation | 500 nm |
| Emission | 536 nm |
| Storage | Store at -20°C |
| Signal | Warning |
| GHSHazardStatements | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 346.13174244 g/mol |
| Monoisotopic Mass | 346.13174244 g/mol |
| Topological Polar Surface Area | 87.6Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 488 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22248218 | 2012-09-01 | Effect of priming in subpopulations of peripheral neutrophils from patients with chronic periodontitis | Journal of periodontology |
| 22768920 | 2012-07-06 | Effects of lipid-probe interactions in biochemical fluorometric methods that assess HDL redox activity | Lipids in health and disease |
| 22497768 | 2012-07-01 | A fluorimetric assay for human reticulocyte 15-lipoxygenase-1 activity | Analytical biochemistry |
| 22545706 | 2012-06-01 | DHR123: an alternative probe for assessment of ROS in human spermatozoa | Systems biology in reproductive medicine |
| 22262438 | 2012-01-01 | Measurement of oxidative burst in neutrophils | Methods in molecular biology (Clifton, N.J.) |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114213419-A | Fluorescent probe with both fluorescence imaging and type I photodynamic/photothermal killing cancer cell activity, preparation method and application thereof | 2021-11-29 |
| CN-114213419-B | A fluorescent probe with both fluorescence imaging and type I photodynamic/photothermal killing activity on cancer cells and its preparation method and application | 2021-11-29 |
| WO-2022078524-A2 | Specific conjugation of an antibody | 2021-11-03 |
| WO-2022078524-A4 | Specific conjugation of an antibody | 2021-11-03 |
| CN-114129725-A | A kind of photodynamically triggered nitric oxide to release black phosphorus nanomaterial and its preparation method and application | 2021-10-28 |
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