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1,3-Propanediamine,N1-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]- | CAS 136587-13-8
| Catalog Number | A03-0006 |
| Category | NO & ROS Probes |
| Molecular Formula | C10H26 N6 O2 |
| Molecular Weight | 262.36 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Releases nitric oxide by spontaneously dissociating in a pH-dependent manner and is useful for reliable and controllable NO generation in solution.
Chemical Information
Product Specification
Application
| Synonyms | Spermine NONOate;(Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE; (Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE; SPERMINE BIS (NITRIC OXIDE) ADDUCT; SPERMINE/NITRIC OXIDE COMPLEX; SPER |
| Purity | ≥97% |
| IUPAC Name | (Z)-[3-aminopropyl-[4-(3-aminopropylamino)butyl]amino]-hydroxyimino-oxidoazanium |
| Canonical SMILES | C(CCN(CCCN)[N+](=NO)[O-])CNCCCN |
| InChI | InChI=1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,17H,1-12H2/b16-14- |
| InChIKey | STVYBUMQUAJDER-PEZBUJJGSA-N |
| Solubility | Soluble in water |
| Density | 1.23 g/cm3 |
| Appearance | Off-White Solid |
| Storage | Store at-10 to-35 °C, Desiccate |
Nitric Oxide Donor Studies: 1,3-Propanediamine, N1-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]- is widely utilized as a nitric oxide (NO) donor in scientific research. It releases NO in a controlled manner, allowing researchers to study the biological roles and mechanisms of this critical signaling molecule. NO is involved in numerous physiological processes, including vasodilation, immune response modulation, and neurotransmission. By providing a reliable source of NO, this compound is instrumental in investigating NO-related pathways and the development of NO-based therapies for cardiovascular diseases, neurodegenerative disorders, and cancer. This application is essential for advancing our understanding of NO's impact on cellular function and disease progression.
Reactive Oxygen Species (ROS) Regulation: This compound also plays a significant role in studies related to reactive oxygen species (ROS) regulation. By modulating ROS levels, researchers can explore the balance between oxidative stress and antioxidant defenses in cells. Excessive ROS production can lead to cellular damage and contribute to the pathogenesis of various conditions, including aging, cancer, and cardiovascular diseases. Using 1,3-Propanediamine, N1-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]- as a tool, scientists can investigate how altering ROS levels affects cell signaling and survival, providing valuable insights for developing strategies to mitigate oxidative stress-related damage.
Cell Signaling and Apoptosis Studies: 1,3-Propanediamine, N1-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]- is also employed in research focused on cell signaling and apoptosis. NO and ROS are key regulators of various signaling pathways that govern cell proliferation, differentiation, and programmed cell death. By using this compound to modulate NO and ROS levels, researchers can study their influence on critical pathways such as the MAPK, PI3K/AKT, and NF-κB signaling cascades. Understanding how these molecules regulate cell fate decisions is crucial for developing therapeutic interventions for diseases characterized by dysregulated cell growth and survival, such as cancer and neurodegenerative disorders.
Drug Development and Testing: This compound is used in drug development and testing as a model to screen and evaluate potential therapeutic agents targeting NO and ROS pathways. Its ability to release NO and affect ROS levels makes it an ideal tool for preclinical studies aimed at identifying new drugs with anti-inflammatory, cardioprotective, or neuroprotective properties. Researchers use this compound to test the efficacy and safety of candidate molecules, helping to optimize their therapeutic potential before advancing to clinical trials. This application is vital for discovering novel treatments for conditions where NO and ROS imbalances play a critical role, including ischemic injury, chronic inflammation, and metabolic disorders.
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