L-NIO hydrochloride | CAS 36889-13-1

Catalog Number	A03-0009
Category	NO & ROS Probes
Molecular Formula	C7H15N3O2·2HCl
Molecular Weight	246.1

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Product Introduction

L-NIO is an irreversible and non-selective inhibitor of all NOS isoforms.

Chemical Information
Product Specification
Application

Related CAS	159190-44-0 (dihydrochloride)
Synonyms	L-NIO;N5-iminoethyl-l-ornithine hydrochloride; N5-(1-Iminoethyl)-L-ornithine hydrochloride; N(G)-Iminoethylornithine hydrochloride
Purity	≥95%
Solubility	Soluble in water or MeOH
Appearance	Crystalline Solid

Storage

Store at-10 to-35 °C, Desiccate

L-NIO hydrochloride, a potent and selective inhibitor of nitric oxide synthase (NOS) with diverse applications in scientific research, is at the forefront of various fields. Below are the key applications of L-NIO hydrochloride:

Neuroscience Research: Delving into neuroscience, L-NIO hydrochloride serves as a pivotal tool for investigating the intricate role of nitric oxide in neurophysiological processes. By blocking NOS activity, researchers can delve into the contributions of nitric oxide in neurotransmission, synaptic plasticity, and neurodegenerative conditions. This exploration aids in unraveling the molecular underpinnings of neurological disorders while guiding the development of innovative therapeutic avenues.

Cardiovascular Studies: Within cardiovascular investigations, L-NIO hydrochloride plays a vital role in unveiling the functions of nitric oxide in vascular dynamics and blood pressure regulation. Through NOS inhibition, researchers can dissect the impacts of nitric oxide on endothelial function, vascular reactivity, and cardiovascular pathologies like hypertension and atherosclerosis. These profound insights are instrumental in formulating targeted strategies for managing cardiovascular ailments.

Immunology Research: Harnessing the power of L-NIO hydrochloride, immunologists delve into the intricacies of nitric oxide’s involvement in immune responses. Nitric oxide emerges as a key player in regulating inflammation and bolstering pathogen defenses within the immune system. By inhibiting NOS, researchers can shed light on nitric oxide’s effects on immune cell activities and inflammatory cascades, offering valuable insights into immune-related conditions and fostering the development of innovative therapeutic interventions.

Cancer Research: In the realm of oncology, L-NIO hydrochloride emerges as a critical tool for investigating the multifaceted roles of nitric oxide in tumor biology. Nitric oxide’s implications in cancer cell proliferation, angiogenesis, and metastasis catalyze groundbreaking research endeavors. Through NOS inhibition facilitated by L-NIO hydrochloride, scientists can meticulously dissect how nitric oxide modulation influences tumor progression, potentially heralding the advent of novel anti-cancer therapeutic modalities.