H-Arg(Me)-OH acetate salt | CAS 53308-83-1

Name: H-Arg(Me)-OH acetate salt
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	A03-0010
Category	NO & ROS Probes
Molecular Formula	C7H16N4O2·C2H4O2
Molecular Weight	248.28

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Product Introduction

H-Arg(Me)-OH acetate salt is a methylated derivative of arginine presented as a stable crystalline powder, commonly utilized in advanced peptide synthesis. Its methyl group modification on the guanidino side chain influences enzyme recognition and substrate specificity, providing a valuable tool for studying post-translational modifications. The acetate salt form enhances solubility and stability, facilitating applications in proteomics and structural biology research. Researchers employ this reagent extensively to investigate arginine methylation's effects on protein function and signaling pathways.

Chemical Information
Product Specification
Application

Synonyms	NG-Monomethyl-L-arginine acetate; L-NMMA acetate; Targinine acetate
Purity	≥98% by HPLC
IUPAC Name	acetic acid;(2S)-2-amino-5-[(N'-methylcarbamimidoyl)amino]pentanoic acid
Canonical SMILES	CC(=O)O.CN=C(N)NCCCC(C(=O)O)N
InChI	InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
InChIKey	IKPNWIGTWUZCKM-JEDNCBNOSA-N
Solubility	Soluble in water
Density	1.2162 g/cm3(rough estimate)
Appearance	White to Off-white Powder
Boiling Point	391.35°C (rough estimate)
Melting Point	179-190°C

Storage

Store at 2-8 °C

H-Arg(Me)-OH acetate salt, a modified variant of the amino acid arginine, finds diverse applications in bioscience research and industry. Here are four key applications of H-Arg(Me)-OH acetate salt:

Peptide Synthesis: Central to solid-phase peptide synthesis, H-Arg(Me)-OH acetate salt enables the creation of modified peptides with potential enhancements in stability or altered biological activity. This capability is paramount for the development of peptide-based therapeutics and investigations into protein-protein interactions, fostering innovation in the realm of molecular biology.

Enzyme Substrate Research: Serving as a crucial substrate in enzyme assays, H-Arg(Me)-OH acetate salt facilitates the study of arginine-modifying enzymes like protein arginine methyltransferases (PRMTs). Researchers leverage this compound to explore enzyme specificity and activity, unraveling enzyme kinetics and identifying prospective inhibitors. These investigations are pivotal for deciphering enzyme functions and driving drug discovery initiatives targeting enzyme-associated disorders.

Cell Signaling Studies: In the arena of cell signaling research, H-Arg(Me)-OH acetate salt emerges as a valuable tool for examining the influence of methylated arginine residues on protein interactions and cellular pathways. Post-translational methylation of arginine residues can profoundly impact protein functionality, and by integrating H-Arg(Me)-OH into experimental setups, scientists can dissect the role of methylation in cellular signaling and regulation, shedding light on intricate molecular mechanisms.

Pharmaceutical Development: Offering potential opportunities in pharmaceutical innovation, H-Arg(Me)-OH acetate salt plays a role in the creation of pharmaceutical agents, particularly in the design of inhibitors or modulators targeting arginine-modifying enzymes. Compounds derived from this salt may possess distinct pharmacological properties, rendering them promising candidates for drug development endeavors. This application stands as a critical step forward in shaping therapeutic strategies for conditions associated with abnormal arginine methylation, driving progress in the field of drug discovery and development.