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Cyanine7.5 carboxylic acid | CAS 1686147-68-1
| Catalog Number | F02-0021 |
| Category | Cyanine7.5 |
| Molecular Formula | C45H49ClN2O2 |
| Molecular Weight | 685.34 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Free unactivated Cyanine7.5 NIR dye carboxylic acid.For coupling and labeling reactions also consider using pre-activated Cyanine7.5 NHS ester.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Related CAS | 1803099-44-6 (chloride) |
| Synonyms | 6-[1,1-dimethyl-2-[2-[3-[2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]benzo[e]indol-3-yl]hexanoic acid;chloride |
| Purity | NMR 1H, HPLC-MS (95%) |
| IUPAC Name | 6-[1,1-dimethyl-2-[2-[3-[2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]benzo[e]indol-3-yl]hexanoic acid;chloride |
| Canonical SMILES | CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC4=CC(=CC=C5C(C6=C(N5CCCCCC(=O)O)C=CC7=CC=CC=C76)(C)C)CCC4)C.[Cl-] |
| InChI | InChI=1S/C45H48N2O2.ClH/c1-44(2)39(46(5)37-25-23-33-16-8-10-18-35(33)42(37)44)27-21-31-14-13-15-32(30-31)22-28-40-45(3,4)43-36-19-11-9-17-34(36)24-26-38(43)47(40)29-12-6-7-20-41(48)49;/h8-11,16-19,21-28,30H,6-7,12-15,20,29H2,1-5H3;1H |
| InChIKey | NENPZWGBKUDTPW-UHFFFAOYSA-N |
| Solubility | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Appearance | green powder |
| ε, L⋅mol-1⋅cm-1 | 223000 |
| Excitation | 788 |
| Emission | 808 |
| Storage | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
Cyanine7.5 carboxylic acid, a fluorescent dye commonly employed in scientific and medical realms, finds diverse applications. Here are four key applications of Cyanine7.5 carboxylic acid:
In Vivo Imaging: Renowned for its near-infrared fluorescence properties, Cyanine7.5 carboxylic acid emerges as a cornerstone in in vivo imaging, enabling profound tissue penetration and minimal background interference. Its prowess in visualizing and tracing biological processes in live organisms proves pivotal for real-time disease progression monitoring and therapeutic intervention assessment.
Molecular Probes: Acting as a molecular probe, Cyanine7.5 carboxylic acid elegantly labels proteins, nucleic acids, and various biomolecules. Through conjugation with specific targets, researchers unveil the intricate whereabouts, interactions, and dynamics of these biomolecules within cellular landscapes. This capability serves as a linchpin for meticulous scrutiny of cellular mechanisms and molecular pathways at a granular level.
Clinical Diagnostics: Embracing its high sensitivity and specificity, Cyanine7.5 carboxylic acid takes center stage in clinical diagnostic arenas, powering immunoassays and nucleic acid detection tests. Its robust fluorescence signal illuminates low-abundance targets within patient samples, elevating diagnostic precision. Notably, this dye plays a vital role in identifying biomarkers for swift disease detection and progression tracking.
Drug Delivery Studies: A linchpin in drug delivery research, Cyanine7.5 carboxylic acid facilitates the labeling and tracking of drug delivery systems like nanoparticles and liposomes. By visualizing the in vivo biodistribution and accumulation of these carriers, researchers fine-tune drug delivery strategies, enhancing therapeutic efficacy. This application stands as a cornerstone for crafting efficient and targeted drug delivery platforms, fostering advancements in medical treatment paradigms.
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 684.3482565 g/mol |
| Monoisotopic Mass | 684.3482565 g/mol |
| Topological Polar Surface Area | 43.6Ų |
| Heavy Atom Count | 50 |
| Formal Charge | 0 |
| Complexity | 1390 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 3 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2016178510-A1 | A coating composition comprising a dye and a method to detect moisture in objects | 2013-08-02 |
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