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ICG-COOH | 181934-09-8
| Catalog Number | F02-0133 |
| Category | Cyanine7.5 |
| Molecular Formula | C45H50N2O5S |
| Molecular Weight | 730.96 |
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Product Introduction
ICG-COOH (Indocyanine Green Carboxylic Acid) is a derivative of indocyanine green (ICG), a fluorescent dye widely used in medical imaging, particularly in near-infrared (NIR) imaging techniques. The addition of a carboxylic acid group (-COOH) to ICG enhances its ability to be conjugated to biomolecules, such as antibodies or peptides, making it more versatile for targeted imaging applications. ICG-COOH retains the strong NIR fluorescence properties of ICG, making it useful for in vivo imaging, surgical guidance, and photothermal therapy, where it provides high tissue penetration and low background interference due to the NIR wavelength.
Chemical Information |
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| Synonyms | 1H-Benz[e]indolium, 2-[7-[3-(5-carboxypentyl)-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt; Cy7.5 Acid(mono SO3); 4-(2-(7-(3-(5-Carboxypentyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate; ICG-carboxylic acid; mono-sulfo-cy7.5 COOH; ICG-Acid |
| Purity | ≥95% |
| IUPAC Name | 4-[2-[7-[3-(5-carboxypentyl)-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate |
| Canonical SMILES | CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)O)C=CC=CC=CC=C4C(C5=C(N4CCCCS(=O)(=O)[O-])C=CC6=CC=CC=C65)(C)C)C |
| InChI | InChI=1S/C45H50N2O5S/c1-44(2)39(46(30-16-8-11-25-41(48)49)37-28-26-33-19-12-14-21-35(33)42(37)44)23-9-6-5-7-10-24-40-45(3,4)43-36-22-15-13-20-34(36)27-29-38(43)47(40)31-17-18-32-53(50,51)52/h5-7,9-10,12-15,19-24,26-29H,8,11,16-18,25,30-32H2,1-4H3,(H-,48,49,50,51,52) |
| InChI Key | HIBVKROMGIHYKL-UHFFFAOYSA-N |
| Solubility | Soluble in Water |
| Appearance | Brown to black solid |
- Product Specification
| Storage | Store at -20 °C |
Applications of Fluorescent Probes & Dyes
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