Boc-aminooxy-PEG1-propargyl | CAS 1895922-72-1

Name: Boc-aminooxy-PEG1-propargyl
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R01-0126
Category	Alkynes
Molecular Formula	C₁₀H₁₇NO₄
Molecular Weight	215.25

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Product Introduction

Boc-aminooxy-PEG1-propargyl is a polyethylene glycol (PEG)-based PROTAC linker. Boc-aminooxy-PEG1-propargyl can be used in the synthesis of a series of PROTACs.

Chemical Information
Product Specification
Application

Synonyms	t-Boc-aminooxy-PEG1-propargyl
Purity	98%
IUPAC Name	tert-butyl N-(2-prop-2-ynoxyethoxy)carbamate
Canonical SMILES	CC(C)(C)OC(=O)NOCCOCC#C
InChI	InChI=1S/C10H17NO4/c1-5-6-13-7-8-14-11-9(12)15-10(2,3)4/h1H,6-8H2,2-4H3,(H,11,12)
InChIKey	OZSAQUGQZCPQSI-UHFFFAOYSA-N
Solubility	DMSO, DCM, DMF

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Boc-aminooxy-PEG1-propargyl, a versatile chemical reagent, plays a pivotal role in bioconjugation and click chemistry. Here are four key applications:

Bioconjugation: In the realm of bioconjugation, Boc-aminooxy-PEG1-propargyl emerges as a powerful tool for facilitating the covalent attachment of biomolecules. This reagent finds extensive utility in linking proteins, peptides, or nucleic acids to diverse molecules or surfaces, forming essential conjugates crucial for diagnostic assays, drug delivery systems, and cutting-edge bioimaging techniques.

Drug Development: At the forefront of drug development, Boc-aminooxy-PEG1-propargyl plays a critical role in crafting prodrugs and targeted therapeutics. By conjugating active pharmaceutical ingredients (APIs) with precise targeting ligands or carriers, researchers can boost drug specificity while minimizing adverse effects. This strategic approach opens avenues for designing more potent and safer pharmaceutical solutions.

Material Science: Delving into material science, this reagent emerges as a precious asset for surface modification and the advancement of functionalized materials. Its application in grafting bioactive molecules onto surfaces elevates their biological interactions, laying the foundation for innovative biosensors, tissue engineering scaffolds, and biocompatible implants crucial for medical advancements.

Peptide and Protein Chemistry: Transitioning into the realms of peptide and protein chemistry, Boc-aminooxy-PEG1-propargyl serves as a precision-oriented instrument for site-specific labeling and modification. Through the introduction of functional groups at specific sites, researchers can explore intricate protein structure-function dynamics and protein-protein interactions. This tailored modification also fuels the development of cutting-edge protein-based therapeutics and diagnostics, spearheading advancements in healthcare solutions and personalized medicine.