BCN Pro Phosphoramidite

Name: BCN Pro Phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R10-0042
Category	BCN Reagents
Molecular Formula	C52H69N4O8P
Molecular Weight	909.12

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Product Introduction

BCN Pro Phosphoramidite is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a hydroxyprolinol-based phosphoramidite moiety. The hydroxyprolinol linker provides a rigid, non-nucleosidic scaffold. The BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.

Chemical Information
Product Specification

Chemical Information

Synonyms	BCN Phosphoramidite (hydroxyprolinol); ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (6-((2S,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamate; ((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (6-((2S,4R)-2-(4,4'-dimethoxytrityloxymethyl)-4-hydroxypyrrolidin-1-yl)-6-oxohexyl)carbamate 2-cyanoethyl N,N-diisopropylphosphoramidite
Purity	≥98%
SMILES	CC(N(C(C)C)P(O[C@H]1CN(C(CCCCCNC(OC[C@H]2[C@]3([C@@]2(CCC#CCC3)[H])[H])=O)=O)[C@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)C1)OCCC#N)C
InChI	InChI=1S/C52H69N4O8P/c1-38(2)56(39(3)4)65(63-33-17-31-53)64-46-34-43(55(35-46)50(57)22-15-10-16-32-54-51(58)61-37-49-47-20-13-7-8-14-21-48(47)49)36-62-52(40-18-11-9-12-19-40,41-23-27-44(59-5)28-24-41)42-25-29-45(60-6)30-26-42/h9,11-12,18-19,23-30,38-39,43,46-49H,10,13-17,20-22,32-37H2,1-6H3,(H,54,58)/t43-,46+,47-,48+,49+,65?/m0/s1
InChIKey	GZJMCSNKUWQHKK-NRJIPUSRSA-N
Appearance	White foam