BCN Phosphoramidite ACH

Name: BCN Phosphoramidite ACH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R10-0041
Category	BCN Reagents
Molecular Formula	C26H42N3O4P
Molecular Weight	491.61

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Product Introduction

BCN Phosphoramidite ACH is a copper-free click chemistry reagent used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group attached to a phosphoramidite moiety with an ACH (aminocyclohexanol) linker. The ACH linker provides a rigid scaffold, while the BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.

Chemical Information

Chemical Information

Synonyms	((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)carbamate; BCN cyclohexyl Phosphoramidite
SMILES	CC(N(P(OC(CC1)CCC1NC(OC[C@@H]2[C@@]3([H])CCC#CCC[C@@]23[H])=O)OCCC#N)C(C)C)C
InChI	InChI=1S/C26H42N3O4P/c1-19(2)29(20(3)4)34(32-17-9-16-27)33-22-14-12-21(13-15-22)28-26(30)31-18-25-23-10-7-5-6-8-11-24(23)25/h19-25H,7-15,17-18H2,1-4H3,(H,28,30)/t21?,22?,23-,24+,25+,34?
InChIKey	WJLQZGOGPRHKDO-YQNCDECVSA-N