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Alkyne-PEG3-NHS ester
| Catalog Number | R01-0003 |
| Category | NHS Esters |
| Molecular Formula | C14H19NO7 |
| Molecular Weight | 313.31 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Alkyne-PEG3-NHS ester is a bifunctional molecule containing NHS ester and alkyne functional groups. NHS ester group is used for the labeling of amine groups, like lysine and N-terminal NH2, in proteins and peptides. And terminal alkyne group is useful for copper catalyzed Click chemistry (CuAAc) or Sonogashira coupling. PEG3 linker is hydrophilic, and provides a good separation between the parts of the conjugate.
Chemical Information
Application
| Purity | NMR 1H, HPLC-MS (95%) |
| Solubility | good in water, many polar organic solvents |
| Appearance | colorless to yellowish oil |
Alkyne-PEG3-NHS ester, a remarkably versatile molecule, stands as a key facilitator for conjugating functional groups across a diverse range of biotechnological applications. Here, with an emphasis on high perplexity and burstiness, are four innovative applications of Alkyne-PEG3-NHS ester:
Bioconjugation: Embedded in bioconjugation protocols, Alkyne-PEG3-NHS ester emerges as a transformative agent for linking biomolecules—be it antibodies, peptides, or proteins—to surfaces or other molecular entities. Through the creation of stable amide bonds with primary amines, this NHS ester empowers the functionalization of biomolecules with alkyne groups. This sets the stage for subsequent click chemistry reactions, enabling precise and specific conjugation applications that propel the boundaries of biotechnological advancements into uncharted territories of innovation.
Drug Delivery: In the domain of drug delivery systems, Alkyne-PEG3-NHS ester assumes a pivotal role in modifying therapeutic agents with PEG chains to enhance their pharmacokinetics and biodistribution. The process of PEGylation significantly boosts solubility, stability, and half-life of drugs, ultimately amplifying their efficacy in combating diseases. The alkyne functional group acts as a crucial anchor point for additional modifications such as targeting ligands or imaging agents, propelling drug delivery strategies into the domain of targeted precision medicine with unparalleled precision and impact.
Surface Functionalization: Alkyne-PEG3-NHS ester’s utilization in surface functionalization for biosensors and diagnostics marks a revolutionary leap in biotechnological innovation. By immobilizing biomolecules on sensor surfaces, this compound elevates the sensitivity and specificity of detection systems, ushering in a new era of diagnostic tools and point-of-care devices that demand swift and reliable biomolecule capture. This cutting-edge approach is reshaping the landscape of biosensing technologies with unmatched precision and reliability.
Chemical Biology: In the realm of chemical biology, Alkyne-PEG3-NHS ester shines as a beacon of innovation, enabling the installation of clickable alkyne groups onto biomolecules for tracking and visualization in dynamic live-cell imaging studies. By empowering researchers to study the dynamic behaviors and interactions of modified biomolecules within their native cellular environments, this compound plays an instrumental role in unraveling biological processes and fostering the development of avant-garde therapeutic strategies.
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