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Alkyne maleimide
| Catalog Number | R02-0006 |
| Category | Alkynes |
| Molecular Formula | C12H14N2O3 |
| Molecular Weight | 234.25 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Alkyne maleimide is a bifunctional linker reagent which allows to attach terminal alkyne to various thiol-containing molecules, such as proteins containing cysteine residues. The alkyne moiety can be then conjugated with various azides via copper-catalyzed Click chemistry reaction.
Chemical Information
Computed Properties
Patents
| Purity | NMR 1H, HPLC-MS (95%) |
| IUPAC Name | N-[2-(2,5-dioxopyrrol-1-yl)ethyl]hex-5-ynamide |
| Canonical SMILES | C#CCCCC(=O)NCCN1C(=O)C=CC1=O |
| InChI | InChI=1S/C12H14N2O3/c1-2-3-4-5-10(15)13-8-9-14-11(16)6-7-12(14)17/h1,6-7H,3-5,8-9H2,(H,13,15) |
| InChIKey | JFWXHCHRKDOVRJ-UHFFFAOYSA-N |
| Solubility | good in DMSO, DMF, alcohols, limited in water |
| Appearance | colorless solid |
| XLogP3 | -0.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 234.10044231 g/mol |
| Monoisotopic Mass | 234.10044231 g/mol |
| Topological Polar Surface Area | 66.5Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 385 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2021260176-A1 | Synthetic epitopes of betacoronaviruses | 2020-06-25 |
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