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8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt | CAS 6358-69-6
| Catalog Number | A15-0017 |
| Category | pH Indicators |
| Molecular Formula | C16H7Na3O10S3 |
| Molecular Weight | 524.39 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt is a hydrophilic, membrane-impermeant pH indicator.
Chemical Information
Product Specification
Application
| Related CAS | 27928-00-3 (free acid) |
| Synonyms | Pyranine concentrated; Pyranine; HPTS; Solvent Green 7; Sodium 8-hydroxypyrene-1,3,6-trisulfonate; 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt; 1,3,6-Pyrenetrisulfonic acid, 8-hydroxy-, sodium salt (1:3); NSC 97285 |
| Purity | ≥85% |
| IUPAC Name | trisodium;8-hydroxypyrene-1,3,6-trisulfonate |
| Canonical SMILES | C1=CC2=C3C(=C(C=C2S(=O)(=O)[O-])S(=O)(=O)[O-])C=CC4=C(C=C(C1=C43)O)S(=O)(=O)[O-].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/C16H10O10S3.3Na/c17-11-5-12(27(18,19)20)8-3-4-10-14(29(24,25)26)6-13(28(21,22)23)9-2-1-7(11)15(8)16(9)10;;;/h1-6,17H,(H,18,19,20)(H,21,22,23)(H,24,25,26);;;/q;3*+1/p-3 |
| InChIKey | KXXXUIKPSVVSAW-UHFFFAOYSA-K |
| Solubility | Soluble in DMSO (Sparingly, Heated), Water (Slightly) |
| Density | 2.15 g/cm3 |
| Appearance | Yellow Solid |
| Boiling Point | 171-178 °C at 10 mmHg (lit.) |
| LogP | 4.24430 |
| Storage | Store at 2-8°C |
8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt is widely utilized in the field of biochemical assays as a fluorescent pH indicator. Its ability to undergo significant fluorescence changes in response to varying pH levels makes it an invaluable tool for monitoring pH in live-cell imaging and other biochemical experiments. This characteristic allows researchers to determine the acidity or alkalinity of cellular environments, providing critical insights into metabolic processes and cellular health. The use of this indicator in real-time applications facilitates a deeper understanding of cellular dynamics, especially in studies involving enzyme activities and metabolic pathways.
Another key application of this compound is in the development of sensor technology. 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt is integrated into pH-sensitive sensors that are employed in environmental monitoring. These sensors can detect changes in pH levels in various aquatic environments, helping to monitor water quality and ecosystem health. By providing accurate and real-time data on pH fluctuations, this compound plays a crucial role in environmental research, assisting in the detection of pollution and the assessment of aquatic habitats.
In the realm of pharmaceuticals, 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt serves as an important component in drug formulation and delivery systems. Its pH-responsive properties can be harnessed to design drug carriers that release therapeutic agents in a controlled manner based on the pH of the target environment. This is particularly useful in developing targeted therapies for diseases, where maintaining optimal drug release at specific pH levels enhances therapeutic efficacy and minimizes side effects. As such, its application in pharmaceutical development significantly advances the creation of smart drug delivery systems.
Lastly, the compound is frequently used in educational and research laboratories for teaching and demonstration purposes. Its vivid fluorescence and clear pH-dependent behavior provide a visually appealing and effective way to demonstrate acid-base chemistry concepts. In academic settings, students can engage with hands-on experiments using this indicator to observe pH changes in various solutions, enhancing their understanding of chemical principles. By bridging theoretical concepts with practical applications, 8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt enriches the educational experience in chemistry and biochemistry courses.
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