4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne | CAS 1351373-46-0

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne is a poly(ethylene glycol)-based diyne building block designed for carbon–carbon bond formation via alkyne reactivity in click chemistry workflows. Its extended, oxygen-rich scaffold provides solubility and spacing control for constructing multivalent conjugates, polymer architectures, and functional biomaterials. The presence of two terminal diyne ends makes it particularly useful as a linker or spacer in research and industrial settings where controlled incorporation of alkyne handles is required for downstream coupling and modular assembly.

1. Multivalent Probe Linkers

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne is commonly used to prepare multivalent research probes by providing two reactive alkyne termini separated by a flexible, hydrophilic PEG-like backbone. In chemical biology and molecular imaging development, this type of linker helps tune distance effects between recognition elements and reporting groups, supporting more consistent conjugate architectures across batches. The oxygen-rich chain also improves aqueous handling during probe formulation and conjugation steps, which is valuable for workflows that require iterative attachment of multiple functional moieties to surfaces, nanoparticles, or soluble biomolecular scaffolds.

2. Surface And Material Functionalization

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne is well suited for functionalizing polymer films, hydrogels, and other material platforms that need defined alkyne handle density for later modular coupling. Materials science groups often incorporate diyne linkers to create patterned or gradient-like functional regions, enabling downstream attachment of bioactive ligands, affinity tags, or imaging reporters through orthogonal click-compatible chemistries. Because the scaffold is flexible and water compatible, it can support uniform coating and reduce aggregation during surface modification, which is frequently important for reproducible material performance in laboratory and industrial R&D.

3. Polymer Architecture And Crosslinking

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne is used as a spacer and reactive component in polymer chemistry to build defined architectures where alkyne functionality must be incorporated at controlled intervals. In polymer and biomaterials development, the diyne motif enables modular assembly routes that can be adapted to different end-group chemistries, allowing researchers to tailor network connectivity, spacing, and solvation behavior. The extended polyether character supports compatibility with aqueous processing and helps maintain processability during formulation of polymer conjugates, coatings, and functional gel systems.

4. Bioconjugation For Targeting Constructs

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne is frequently selected as an alkyne-containing linker for bioconjugation workflows that require a stable, flexible connection between biomolecular targeting elements and downstream labels or capture handles. Chemical biology teams use such PEG-like diyne linkers to manage conjugate geometry, improving accessibility of attached groups and supporting consistent conjugation across different biomolecule formats such as proteins, peptides, and nucleic-acid related constructs. The dual alkyne ends also make it convenient for stepwise build strategies where one end is reserved for subsequent coupling while the other is used to anchor the linker to a pre-functionalized partner.

5. Diagnostic Reagent And Imaging Tool Building

4,7,10,13,16,19,22,25-Octaoxaoctacosa-1,27-diyne supports the modular construction of diagnostic reagent components and analytical imaging tools that rely on click-compatible alkyne handles. Research reagent developers use diyne linkers to standardize the attachment of reporting groups, affinity moieties, or scaffold elements into multicomponent probe systems, helping streamline the assembly of libraries for method development. The hydrophilic, oxygen-rich backbone is particularly helpful when preparing reagent formulations that must remain soluble and stable during handling, storage, and iterative optimization in laboratory workflows.