4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne | CAS 1351373-47-1

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne is a long-chain, multi-ether substituted diyne designed for click chemistry workflows where two terminal alkyne handles enable efficient covalent coupling to complementary azide- or cyclooctyne-bearing partners. As a difunctional alkyne reagent, it is commonly used as a modular linker or scaffold component in materials and probe construction, offering a flexible, ether-rich spacer that can reduce nonspecific interactions and improve solubility in aqueous or mixed solvent environments. Its extended geometry and two reactive termini make it particularly relevant for assembling multivalent conjugates, crosslinked networks, and imaging or assay reagents that require defined alkyne spacing.

1. Multivalent Probe Conjugation

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne is used to build multivalent chemical probes by coupling both diyne termini to azide-functional targeting motifs, affinity handles, or reporter-bearing constructs. In chemical biology and molecular imaging research, this reagent helps researchers generate higher-order conjugates where the distance between binding or recognition elements is tuned by the length of the spacer. The ether-rich backbone often supports compatibility with aqueous labeling buffers and helps maintain probe behavior during conjugation and downstream purification, making it a practical choice for assembling libraries of azide-functionalized ligands, biomolecule tags, or polymer-supported reporters.

2. Surface and Hydrogel Patterning

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne is applied in surface functionalization and hydrogel or polymer network construction where diyne linkers are needed to connect azide-bearing substrates to create patterned or crosslinked architectures. Materials scientists frequently use difunctional alkyne reagents to control crosslink density and spatial organization in biointerfaces, including coatings for biosensing platforms and patterned surfaces for microscopy-based assays. The long, flexible spacer provided by the decaoxatetratriaconta framework can help accommodate surface roughness and reduce steric crowding, supporting more uniform attachment of azide-functional materials and improving reproducibility across batch-to-batch surface preparations.

3. Polymer Backbone Crosslinking

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne serves as a linker for polymer crosslinking strategies that rely on orthogonal click-compatible functional groups. In biomaterials development, it is commonly incorporated into formulations where azide-functional polymers, block copolymers, or polymeric carriers are connected to form stable networks, micellar assemblies, or mechanically reinforced hydrogels. The two alkyne termini allow network formation through dual-point coupling, while the ether-rich chain can influence swelling behavior and solvation characteristics, which is valuable when researchers need consistent material handling for downstream processing such as casting, molding, or nanoparticle fabrication.

4. Imaging and Diagnostic Reagent Platforms

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne is used to assemble imaging and diagnostic reagent platforms that require controlled linker length between a reporter and a recognition element. Molecular imaging and assay development teams often select difunctional alkyne linkers to connect azide-functional fluorophores, quencher groups, affinity tags, or solid-support capture chemistries, enabling systematic variation of spacing to optimize signal-to-background in assay readouts. The extended, flexible spacer can also reduce conformational constraints that sometimes accompany shorter linkers, supporting robust labeling workflows for probe generation, reagent conjugate libraries, and multiplexed detection formats.

5. Nanoparticle and Bead Functionalization

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriaconta-1,33-diyne is widely used for nanoparticle and solid-support bead functionalization where dual alkyne reactivity enables stable attachment of azide-bearing components to particle surfaces. In research settings focused on chemical biology tools and high-throughput screening, this reagent supports the construction of multivalent particle conjugates, including bead-based capture reagents and surface-decorated nanoparticles used for binding assays and separation workflows. The ether-rich linker architecture helps maintain colloidal compatibility during conjugation and washing steps, which is important for preserving functional surface density and ensuring consistent performance across repeated reagent batches.