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Indo-1 sodium salt
| Catalog Number | A14-0020 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C32H26N3Na5O12 |
| Molecular Weight | 759.5 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0020 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Indo-1 is a ratiometric fluorescent indicator for calcium. Indo-1 is useful for flow cytometry. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium.
Chemical Information
Product Specification
Application
| Related CAS | 96314-96-4 (free acid) |
| Synonyms | 1-[2-amino-5-(6-carboxyindol-2-yl)phenoxyl-2-(2'-amino-5'-methyl-phenoxy)ethane]-N,N,N',N'-tetraacetic acid, pentasodium salt |
| Purity | ≥90% |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=C(C=CC(=C2)C3=CC4=C(N3)C=C(C=C4)C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/C32H31N3O12.5Na/c1-18-2-6-24(34(14-28(36)37)15-29(38)39)26(10-18)46-8-9-47-27-13-20(5-7-25(27)35(16-30(40)41)17-31(42)43)22-11-19-3-4-21(32(44)45)12-23(19)33-22;;;;;/h2-7,10-13,33H,8-9,14-17H2,1H3,(H,36,37)(H,38,39)(H,40,41)(H,42,43)(H,44,45);;;;;/q;5*+1/p-5 |
| InChIKey | LFNRCUIINCZPOA-UHFFFAOYSA-I |
| Appearance | Solid Powder |
| Excitation | 349-364 nm |
| Emission | 475-485 nm (no Ca2+), 400-410 nm (Ca2+-bound) |
| Storage | Store at -20°C |
Indo-1 sodium salt, a prominent fluorescent calcium indicator, finds widespread application in diverse biological and biomedical research endeavors.
Intracellular Calcium Imaging: Indo-1 sodium salt emerges as a pivotal tool for scrutinizing fluctuations in intracellular calcium levels, offering profound insights into the intricacies of cellular signaling cascades. Its unique ability to emit fluorescence at distinct wavelengths upon binding calcium enables precise ratiometric imaging techniques. This method proves indispensable for unraveling the dynamic calcium scenarios within neurons, muscle cells, and a myriad of other cellular categories.
High-Throughput Screening: Delving into the realm of drug discovery, Indo-1 sodium salt plays a critical role in high-throughput screening assays designed to pinpoint compounds that modulate calcium-mediated signaling pathways. Utilizing fluorescence-based metrics, researchers can swiftly evaluate the impact of numerous compounds on intracellular calcium levels, expediting the screening process for potential drug candidates targeting calcium-related maladies.
Cardiac Physiology Studies: Within the realm of cardiac research, Indo-1 sodium salt serves as a key player in elucidating the intricate calcium flux dynamics within cardiac cells, a hallmark of comprehending cardiac functionality and pathophysiology. Researchers leverage this indicator to track real-time alterations in calcium concentrations throughout the cardiac cycle, shedding light on arrhythmias and other cardiac anomalies, thereby aiding in the formulation of therapeutic interventions for heart-related conditions.
Neuroscience Research: In the domain of neuroscience, Indo-1 sodium salt emerges as an indispensable ally for exploring the nuances of calcium signaling in neuronal networks and synaptic junctions. Through the visualization of calcium spikes and oscillations, researchers gain deeper insights into neuronal activities, synaptic plasticity, and network connectivity. This application contributes significantly to unraveling the labyrinthine mechanisms underpinning brain function and the onset of neurological ailments.
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