Quin-2 AM | CAS 83104-85-2

Catalog Number	A14-0019
Category	Calcium, Chloride and Other indicators
Molecular Formula	C38H43N3O18
Molecular Weight	829.8

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Product Introduction

Quin-2 AM is a cell-permeant acetoxymethyl ester of quin-2, a high affinity fluorescent calcium indicator. It is hydrolyzed by intracellular esterases to produce quin-2. As quin-2 is highly selective for calcium, it it suitable for monitoring low levels of calcium.

Chemical Information
Product Specification
Application

Synonyms	Quin-2 Acetoxymethyl ester; N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-glycine(acetyloxy)methyl ester
Purity	≥90%
Canonical SMILES	CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCC2=NC3=C(C=C(C=C3C=C2)OC)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
InChI	InChI=1S/C38H43N3O18/c1-23-7-10-31(40(14-34(46)56-19-52-24(2)42)15-35(47)57-20-53-25(3)43)33(11-23)51-18-29-9-8-28-12-30(50-6)13-32(38(28)39-29)41(16-36(48)58-21-54-26(4)44)17-37(49)59-22-55-27(5)45/h7-13H,14-22H2,1-6H3
InChIKey	ANRZUBSJAOAXHS-UHFFFAOYSA-N
Appearance	Solid Powder

Excitation	339 nm
Emission	492 nm
Storage	Store at -20°C

Quin-2 AM, a prominent calcium indicator in biological research, empowers the measurement and visualization of intracellular calcium levels. Here are four key applications of Quin-2 AM, articulated with high perplexity and burstiness:

Calcium Signaling Studies: Playing a pivotal role in unraveling calcium signaling pathways within cells, Quin-2 AM serves as a potent tool for researchers. By imbuing cells with this luminescent dye, scientists can track dynamic fluctuations in intracellular calcium levels in real time, unveiling the intricate responses to diverse stimuli. This illuminates crucial insights into cellular processes like muscle contraction, neurotransmitter release, and cellular demise.

Neuroscience Research: Delving into the realm of neuroscience, Quin-2 AM facilitates the exploration of calcium dynamics in neurons and other components of the nervous system. Through visualizing the fluxes of calcium ions, scientists can probe into the involvement of calcium in synaptic transmission and plasticity. These investigations are indispensable for deciphering the mechanisms that underlie learning, memory, and the complexities of neurological disorders.

Pharmacological Testing: In the arena of drug evaluation and refinement, Quin-2 AM emerges as a key player in assessing the impacts of pharmacological compounds on calcium homeostasis. Researchers leverage Quin-2 AM-loaded cells to scrutinize how different drugs influence calcium signaling, aiding in the identification of potential drug candidates. This screening process aids in pinpointing compounds that exhibit promise in treating conditions linked to calcium perturbations, such as cardiac arrhythmias and select neurodegenerative disorders.

Toxicology Studies: Embracing a crucial role in toxicological inquiries, Quin-2 AM proves invaluable in gauging the detrimental effects of chemicals and environmental toxins on calcium signaling. By scrutinizing alterations in calcium levels triggered by toxic substances, researchers gain deeper insights into the pathways of cellular harm and stress. This knowledge forms the bedrock for devising strategies to mitigate toxic outcomes, safeguarding environmental and health realms against potential dangers.