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Rhod-2 AM | CAS 129787-64-0
| Catalog Number | A14-0068 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C52H59N4O19Br |
| Molecular Weight | 1123.96 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0068 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Rhod-2 AM is a cell-permeable fluorescent Ca2+ indicator. It can be loaded into cells via incubation, and hydrolyzed to rhod-2 by endogenous esterases, producing fluorescence upon binding to intracellular Ca2+.
Chemical Information
Application
| Related CAS | 723730-36-7 (free base) |
| Synonyms | [9-[4-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-3-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium bromide |
| Canonical SMILES | CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC(=C2)C3=C4C=CC(=[N+](C)C)C=C4OC5=C3C=CC(=C5)N(C)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C.[Br-] |
| InChI | InChI=1S/C52H59N4O19.BrH/c1-32-10-16-42(55(24-48(61)71-28-67-33(2)57)25-49(62)72-29-68-34(3)58)46(20-32)65-18-19-66-47-21-37(11-17-43(47)56(26-50(63)73-30-69-35(4)59)27-51(64)74-31-70-36(5)60)52-40-14-12-38(53(6)7)22-44(40)75-45-23-39(54(8)9)13-15-41(45)52;/h10-17,20-23H,18-19,24-31H2,1-9H3;1H/q+1;/p-1 |
| InChIKey | RWXWZOWDWYQKBK-UHFFFAOYSA-M |
| Appearance | Solid Powder |
Rhod-2 AM, a fluorescent calcium indicator, serves as a valuable tool for measuring intracellular calcium levels across diverse biological contexts. Here are four key applications of Rhod-2 AM:
Cardiac Research: In the realm of cardiac research, Rhod-2 AM emerges as a prominent player, facilitating the visualization and quantification of calcium transients within cardiac cells. Understanding calcium signaling holds paramount importance in deciphering the intricacies of cardiac myocyte function, arrhythmias, and heart disease dynamics. This indicator empowers researchers to track real-time calcium fluctuations and explore the impact of pharmacological agents on cardiac performance in a dynamic and insightful manner.
Neuroscience: Within the domain of neuroscience, Rhod-2 AM stands out as a crucial element in unraveling the mysteries of calcium signaling within neurons and glial cells. Calcium ions, acting as pivotal players in synaptic transmission and plasticity, profoundly influence overall neuronal functionality. By employing Rhod-2 AM, scientists gain the ability to witness and analyze calcium waves and oscillations, shedding light on brain function intricacies and the pathology of neurological disorders through a nuanced and detailed lens.
Muscle Physiology: Delving into the realm of muscle physiology, Rhod-2 AM emerges as a pivotal asset for investigating calcium dynamics within both skeletal and smooth muscle tissues. Calcium ions, acting as primary regulators of muscle contraction and relaxation processes, dictate the functional mechanisms of these tissues. By leveraging this indicator, researchers can delve into muscle physiology intricacies, dissect the mechanisms underlying muscle diseases, and evaluate the efficacy of therapeutic interventions with a detailed and comprehensive approach.
Cellular Toxicology: In the sphere of cellular toxicology, Rhod-2 AM plays a crucial role in evaluating the impact of various compounds on intracellular calcium levels, serving as a key indicator of cellular stress or damage. Disruptions in calcium homeostasis offer insights into potential cytotoxic effects induced by drugs, environmental toxins, and other chemicals. Through continuous monitoring of calcium fluctuations with Rhod-2 AM, scientists can gain a deeper understanding of how different compounds affect various cell types.
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