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BAPTA tetrapotassium Salt | CAS 73630-08-7
| Catalog Number | A14-0125 |
| Category | Calcium, Chloride and Other indicators |
| Molecular Formula | C22H20K4N2O10 |
| Molecular Weight | 628.80 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
BAPTA tetrapotassium salt is a water-soluble, cell membrane-impermeant metal chelator that is relatively selective for Ca2+ ions.
Chemical Information
Application
| Related CAS | 85233-19-8 (free acid) |
| Canonical SMILES | C1=CC=C(C(=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC=CC=C2N(CC(=O)[O-])CC(=O)[O-].[K+].[K+].[K+].[K+] |
| InChI | InChI=1S/C22H24N2O10.4K/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4 |
| InChIKey | MAWIDOKQOLSOFT-UHFFFAOYSA-J |
| Appearance | Solid Powder |
BAPTA tetrapotassium salt is widely used as a calcium chelating agent. One of its primary applications is in neurobiology, where it is employed to study calcium signaling in neurons. Calcium ions play a critical role in various neuronal functions, such as synaptic transmission, plasticity, and excitotoxicity. BAPTA is known for its high selectivity for calcium ions (Ca2+) over magnesium ions (Mg2+). Using BAPTA, researchers can precisely control the intracellular calcium concentrations to study the effects of calcium fluctuations on neuronal activities. By buffering calcium ions, BAPTA can prevent calcium-mediated neurotoxicity, thereby providing insights into neurodegenerative diseases and potential therapeutic interventions.
Another significant application of BAPTA tetrapotassium salt is in cardiac physiology research. Calcium ions are vital for the contraction and relaxation of cardiac muscles. BAPTA is used to investigate the calcium-dependent mechanisms that underlie cardiac muscle function and dysfunction. By chelating intracellular calcium, BAPTA allows researchers to delineate the role of calcium transients in excitation-contraction coupling and arrhythmogenesis. Additionally, it is used to study the effects of calcium ion concentration on heart muscle hypertrophy and heart failure. As such, BAPTA helps in identifying new targets for treating heart diseases and improving cardiac health.
BAPTA tetrapotassium salt is also utilized extensively in cell biology for its ability to regulate calcium-dependent cellular processes. Calcium ions are crucial secondary messengers in numerous cellular pathways, including those involved in cell division, differentiation, apoptosis, and motility. By modulating intracellular calcium levels, BAPTA aids in the dissection of these pathways and understanding their implications in health and disease. For example, in cancer research, BAPTA can be used to study how altered calcium signaling contributes to cancer cell proliferation and metastasis. This information can be instrumental in developing calcium-based therapeutic strategies against cancer.
In the field of immunology, BAPTA tetrapotassium salt is valuable for studying calcium signaling in immune cells. Calcium ions are important for the activation and function of various immune cells, such as T cells, B cells, and macrophages. BAPTA is employed to buffer calcium changes within these cells, thereby helping to elucidate the role of calcium in immune responses. It is particularly useful in research focused on understanding how calcium signaling influences processes like cytokine production, immune cell activation, and pathogen response. Through such studies, BAPTA contributes to the development of interventions aimed at modulating immune functions in autoimmune diseases and infections.
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