FAM alkyne, 5-isomer

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FAM alkyne, 5-isomer

FAM alkyne, 5-isomer | 510758-19-7

Catelog Number R02-0026
Category Fluorescein FAM
Molecular Formula C25H15O6N
Molecular Weight 413.38
Catalog Number Size Price Quantity
R02-0026 -- $--

Product Introduction

FAM (fluorescein) alkyne for copper-catalyzed Click chemistry, high purity (97+%) 5-isomer. The compound possesses significant aqueous solubility.

Chemical Information

Synonyms 5-FAM-Alkyne; 3',6'-dihydroxy-3-oxo-N-(prop-2-yn-1-yl)-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamide; 3',6'-dihydroxy-3-oxo-N-prop-2-ynylspiro[2-benzofuran-1,9'-xanthene]-5-carboxamide; FAM alkyne; 5-FAM alkyne; 5-carboxyfluorescein, propargylamide
Purity NMR 1H, HPLC-MS (95%)
IUPAC Name 3',6'-dihydroxy-3-oxo-N-prop-2-ynylspiro[2-benzofuran-1,9'-xanthene]-5-carboxamide
Canonical SMILES C#CCNC(=O)C1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O
InChI InChI=1S/C24H15NO6/c1-2-9-25-22(28)13-3-6-17-16(10-13)23(29)31-24(17)18-7-4-14(26)11-20(18)30-21-12-15(27)5-8-19(21)24/h1,3-8,10-12,26-27H,9H2,(H,25,28)
InChI Key UNBAJBIGCBVWJU-UHFFFAOYSA-N
Solubility good in aqueous buffers (pH > 8), alcohols, DMSO, DMF
Appearance yellow solid

Product Specification

ε, L⋅mol-1⋅cm-1 80000
Fluorescence Quantum Yield 0.93
Excitation 490
Emission 513
Storage 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
Signal Warning
GHS Hazard Statements H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement Codes P264, P270, P301+P317, P330, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties

XLogP3 2.8
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 2
Exact Mass 413.08993720 g/mol
Monoisotopic Mass 413.08993720 g/mol
Topological Polar Surface Area 105Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 762
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2019030284-A1 NOVEL TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF 2017-08-09
US-2020239426-A1 Targeted cytotoxic ratjadone derivatives and conjugates thereof 2017-08-09
US-11236059-B2 Targeted cytotoxic ratjadone derivatives and conjugates thereof 2017-08-09
WO-2018151810-A1 Defining rna-small molecule affinity landscapes enables design of a small molecular inhibitor of an oncogenic non-coding rna 2017-02-17
EP-3030548-A1 Transcriptome-wide design of selective, bioactive small molecules targeting rna 2013-08-09
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