7-Nitroindazole

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7-Nitroindazole

7-Nitroindazole | 2942-42-9

Catelog Number A03-0007
Category Nitric Oxide (NO) & Reactive Oxygen Species (ROS)
Molecular Formula C7H5N3O2
Molecular Weight 163.14
Catalog Number Size Price Quantity
A03-0007 -- $--
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Product Introduction

7-Nitroindazole is a nitric oxide synthase inhibitor.

Chemical Information
Synonyms 7-Nitroindazole (7-NI);1H-Indazole, 7-nitro-; NSC 72843
Purity ≥98% by HPLC
IUPAC Name 7-nitro-1H-indazole
Canonical SMILES C1=CC2=C(C(=C1)[N+](=O)[O-])NN=C2
InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
InChI Key PQCAUHUKTBHUSA-UHFFFAOYSA-N
Solubility Soluble in DMSO (Slightly), Methanol (Slightly)
Density 1.525±0.06 g/cm3
Appearance Pale Yellow to Yellow Solid
Boiling Point 383.3±15.0°C at 760 mmHg
Melting Point 186.5-187.5°C

Product Specification
Storage Store at -20°C
Signal Danger
GHS Hazard Statements H301 (86.67%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (11.11%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (97.78%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H341 (11.11%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H351 (86.67%): Suspected of causing cancer [Warning Carcinogenicity] H360 (86.67%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Precautionary Statement Codes P203, P264, P264+P265, P270, P280, P281, P301+P316, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 0
Exact Mass 163.038176411 g/mol
Monoisotopic Mass 163.038176411 g/mol
Topological Polar Surface Area 74.5Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 192
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
36162621 2022-10-01 N-isopropylbenzylamine, a methamphetamine mimics, produces toxicity via increasing nitric oxide in vitro Toxicology
23571415 2013-06-01 Structure-based identification of OATP1B1/3 inhibitors Molecular pharmacology
22879052 2013-01-01 Renal oxygenation and function of the rat kidney: effects of inspired oxygen and preglomerular oxygen shunting Advances in experimental medicine and biology
22877786 2012-12-01 7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease Neuropharmacology
22884925 2012-12-01 The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat Behavioural brain research

Patents

Publication NumberTitlePriority Date
CN-114146092-A Hyaluronic acid fragment, application of preparation thereof and quality control activity detection method 2021-11-15
CN-113912542-A Method for directly ammoniating nitro nitrogen heterocyclic compound 2021-10-09
WO-2022239001-A1 Pharmaceutical compositions for treating neurological conditions 2021-05-10
US-2022331395-A1 Extended-release injectable gel formulations containing angiotensin-(1-7) oligopeptides or variants thereof 2021-04-07
WO-2022216941-A1 Extended-release injectable gel formulations containing angiotensin-(1-7) oligopeptides or variants thereof 2021-04-07

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