2-Aminopurine Dihydrochloride

What We Offer

2-Aminopurine Dihydrochloride

2-Aminopurine Dihydrochloride | 1428126-74-2

Catalog Number A19-0002
Category DNA Stains
Molecular Formula C5H5N5·2HCl
Molecular Weight 208.1
Catalog Number Size Price Quantity
A19-0002 -- $--

Product Introduction

2-Aminopurine is a fluorescent analog of guanosine and adenosine, and can be used as a DNA probe for structural dynamics and charge transfer.

Chemical Information

Related CAS 452-06-2 (free base)
Synonyms 9H-purin-2-amine, dihydrochloride; 2-AP
Purity ≥98%
IUPAC Name 7H-purin-2-amine;dihydrochloride
Canonical SMILES C1=C2C(=NC(=N1)N)N=CN2.Cl.Cl
InChI InChI=1S/C5H5N5.2ClH/c6-5-7-1-3-4(10-5)9-2-8-3;;/h1-2H,(H3,6,7,8,9,10);2*1H
InChI Key ZMYNIVFDDGHSJU-UHFFFAOYSA-N
Appearance Off-white to Pale Yellow Solid
  • Product Specification
  • Application
Storage Store at -20°C

2-Aminopurine Dihydrochloride, a versatile chemical compound extensively utilized in molecular biology and biochemistry research, offers a plethora of applications. Here are four key applications of 2-Aminopurine Dihydrochloride:

Mutagenesis Studies: Serving as a potent mutagen in genetic investigations, 2-Aminopurine Dihydrochloride plays a pivotal role in inducing base-pair substitutions during DNA replication. By integrating into DNA in lieu of adenine or guanine, it triggers mispairing, leading to mutations. This mechanism aids researchers in unraveling mutation pathways, exploring gene functionality, and dissecting gene regulation intricacies.

Fluorescent Tagging: Positioned as a luminous counterpart to adenine, 2-Aminopurine Dihydrochloride is instrumental in scrutinizing nucleic acid interactions and dynamics. This compound enables real-time monitoring of DNA and RNA structural alterations through fluorescence spectroscopy. Such visualization techniques offer invaluable insights into molecular processes like DNA replication, repair, and transcription, augmenting our understanding of genetic mechanisms.

Protein-DNA Interactions: Employed to investigate protein-DNA couplings, 2-Aminopurine Dihydrochloride’s fluorescence is extinguished upon direct protein contact. By monitoring fluorescence modifications, researchers can assess binding strengths and kinetics of DNA-binding proteins. This data is imperative for deciphering transcriptional control mechanisms and comprehending DNA repair processes in depth.

Structural Biology: Within the domain of structural biology, 2-Aminopurine Dihydrochloride facilitates the exploration of nucleic acid structures and dynamics. Its integration into DNA permits the analysis of helical stability and identification of structural transitions. This capability proves invaluable for studying DNA-protein interactions and evaluating the impact of mutations on DNA stability, enriching our insights into molecular interactions within biological systems.

Computed Properties

Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 0
Exact Mass 207.0078506 g/mol
Monoisotopic Mass 207.0078506 g/mol
Topological Polar Surface Area 80.5Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 127
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 3
Compound Is Canonicalized Yes
cartIcon
Inquiry Basket