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TAMRA-PEG3-biotin | CAS 2279944-59-9
| Catalog Number | F07-0029 |
| Category | TAMRA Dyes |
| Molecular Formula | C₄₃H₅₄N₆O₉S |
| Molecular Weight | 830.99 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TAMRA-PEG3-biotin is a polyethylene glycol (PEG)-based PROTAC linker. TAMRA-PEG3-biotin can be used in the synthesis of a series of PROTACs.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | TAMRA-PEG3-DL-biotin; N-(2-{2-[2-(2-{[3',6'-bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-5-{2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl}pentanamide |
| Purity | 831.0 |
| IUPAC Name | 3',6'-bis(dimethylamino)-3-oxo-N-[2-[2-[2-[2-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]ethoxy]ethoxy]ethoxy]ethyl]spiro[2-benzofuran-1,9'-xanthene]-5-carboxamide |
| Canonical SMILES | CN(C)C1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)C(=O)NCCOCCOCCOCCNC(=O)CCCCC5C6C(CS5)NC(=O)N6)C(=O)O3)C7=C(O2)C=C(C=C7)N(C)C |
| InChI | InChI=1S/C43H54N6O9S/c1-48(2)28-10-13-32-35(24-28)57-36-25-29(49(3)4)11-14-33(36)43(32)31-12-9-27(23-30(31)41(52)58-43)40(51)45-16-18-55-20-22-56-21-19-54-17-15-44-38(50)8-6-5-7-37-39-34(26-59-37)46-42(53)47-39/h9-14,23-25,34,37,39H,5-8,15-22,26H2,1-4H3,(H,44,50)(H,45,51)(H2,46,47,53) |
| InChIKey | BWYKRFATNNMLLL-UHFFFAOYSA-N |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
TAMRA-PEG3-biotin is a multifunctional reagent combining fluorescent labeling and biotin binding capabilities, widely used in various biological and biochemical applications. Here are some key applications of TAMRA-PEG3-biotin:
Fluorescence Microscopy: TAMRA-PEG3-biotin is often used in fluorescence microscopy to label and visualize biomolecules within cells or tissue samples. The fluorescent TAMRA moiety allows precise imaging, enabling researchers to track the localization and dynamics of target molecules. This application is crucial for studying cellular structures, functions, and interactions.
Protein-Protein Interaction Studies: TAMRA-PEG3-biotin can be used to study protein-protein interactions by employing biotin-streptavidin affinity binding. By attaching TAMRA-PEG3-biotin to one protein, researchers can use streptavidin-linked detection systems to identify and analyze interacting partners. This technique is fundamental for investigating complex biological networks and pathways.
Biotinylation of Biomolecules: TAMRA-PEG3-biotin is employed in the biotinylation of various biomolecules, such as nucleic acids, proteins, and antibodies. The biotinylated molecules can subsequently be captured and detected using streptavidin-coated surfaces or beads. This application facilitates numerous assays, including ELISA, Western blots, and affinity purification.
Cell Surface Labeling: TAMRA-PEG3-biotin is useful for labeling cell surface proteins to study cell signaling and communication. The PEG linker provides flexibility and reduces steric hindrance, ensuring effective binding to target proteins without disturbing their functions. This labeling approach aids in the analysis of receptor distribution, endocytosis, and cell-to-cell interactions.
| XLogP3 | 3.1 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 20 |
| Exact Mass | 830.36729849 g/mol |
| Monoisotopic Mass | 830.36729849 g/mol |
| Topological Polar Surface Area | 194Ų |
| Heavy Atom Count | 59 |
| Formal Charge | 0 |
| Complexity | 1410 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 3 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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